|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
anaphylaxis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
It is a clinical diagnosis, although measurement of serial serum total mast cell tryptase (MCT) is gold standard and may help differentiate anaphylaxis from its mimics.
|
31024519 |
2019 |
|
anaphylaxis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Mast cell tryptase is unreliable when used to predict the likelihood of IgE-mediated anaphylaxis to teicoplanin.
|
29319891 |
2018 |
|
anaphylaxis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Serum mast cell tryptase is used to support the diagnosis of anaphylaxis.
|
29331682 |
2018 |
|
anaphylaxis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The measurement of mast cell tryptase is commonly used to support the diagnosis of anaphylaxis.
|
29159510 |
2018 |
|
anaphylaxis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
There is no standardized method for assessing serum total mast cell tryptase (MCT) in anaphylaxis.
|
28609557 |
2017 |
|
anaphylaxis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
In 72 patients, 37 (51%) had severe anaphylaxis, 33 (60%) were histamine positive, and 47 (70%) were mast cell tryptase positive.
|
27906487 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression.
|
31506436 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Histopathological, immunohistochemical, and flow cytometry studies of the resection specimens showed the tumor to be mostly composed of CD117-positive and mast cell tryptase-positive cells with features consistent with mast cell sarcoma.
|
28992848 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Dual-immunostaining for mast cell tryptase and epithelial cytokeratin-8 and whole slide image analysis were used to assess total mast cell number, mast cell density (mast cell number/tissue area), and mast cell number per epithelial or stromal area in TMA spots containing tumor (up to 4 per man).
|
27868214 |
2017 |
|
Asthma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The percentage of macrophages correlated negatively with the expression of mast cell tryptase and ECP in COPD, and with CXCL8 in asthma.
|
27739024 |
2018 |
|
Mastocytosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Formalin-fixed specimens of 35 patients with vulvodynia were evaluated immunohistochemically with antibodies to CD 3,4,8,20,117c and human mast cell tryptase, and for WHO-criteria of neoplastic mastocytosis (>25% spindled mast cell, CD25 expression, point mutations of the c-kit gene (D816V), and chronically elevated serum tryptase levels).
|
25912132 |
2015 |
|
Mastocytosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Serum mast cell tryptase levels are used as a diagnostic criterion and surrogate marker of disease severity in mastocytosis.
|
17449330 |
2007 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Asthma is characterized by bronchial inflammation and hyperresponsiveness that involves mast cell tryptase and potentially its specific receptor protease activated receptor 2 (PAR-2).
|
16195539 |
2006 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Mast cell tryptase - Marker and maker of cardiovascular diseases.
|
30877022 |
2019 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, total IgE and mast cell tryptase were measured in a series of forensic autopsy cases including non-allergic cardiac deaths (14 cases with minimal or no coronary atherosclerosis, 14 cases with significant coronary artery atherosclerosis without acute coronary thrombosis, and 14 cases with significant coronary artery atherosclerosis and acute coronary thrombosis or myocardial infarction) and non-allergic non-cardiac deaths (21 cases with death due to hanging and 21 cases with death due to intracranial gunshot wounds), in order to correlate laboratory results with morphological findings and compare them to conclusions reported in the clinical setting.
|
30599216 |
2019 |
|
Coronary Thrombosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, total IgE and mast cell tryptase were measured in a series of forensic autopsy cases including non-allergic cardiac deaths (14 cases with minimal or no coronary atherosclerosis, 14 cases with significant coronary artery atherosclerosis without acute coronary thrombosis, and 14 cases with significant coronary artery atherosclerosis and acute coronary thrombosis or myocardial infarction) and non-allergic non-cardiac deaths (21 cases with death due to hanging and 21 cases with death due to intracranial gunshot wounds), in order to correlate laboratory results with morphological findings and compare them to conclusions reported in the clinical setting.
|
30599216 |
2019 |
|
Interstitial Cystitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of tissue necrotic factor-α, vascular endothelial growth factor, CD31, transforming growth factor-β and SLUG was significantly increased in non-Hunner type interstitial cystitis and Hunner type interstitial cystitis patients compared with controls whereas the significant increases in the expression of mast cell tryptase and collagen were observed in Hunner type interstitial cystitis patients compared with controls and non-Hunner type interstitial cystitis patients.
|
31144750 |
2019 |
|
Chronic interstitial cystitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of tissue necrotic factor-α, vascular endothelial growth factor, CD31, transforming growth factor-β and SLUG was significantly increased in non-Hunner type interstitial cystitis and Hunner type interstitial cystitis patients compared with controls whereas the significant increases in the expression of mast cell tryptase and collagen were observed in Hunner type interstitial cystitis patients compared with controls and non-Hunner type interstitial cystitis patients.
|
31144750 |
2019 |
|
Mast-Cell Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histopathological, immunohistochemical, and flow cytometry studies of the resection specimens showed the tumor to be mostly composed of CD117-positive and mast cell tryptase-positive cells with features consistent with mast cell sarcoma.
|
28992848 |
2018 |
|
Contracture of joint
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum Mast Cell Tryptase as a Marker of Posttraumatic Joint Contracture in a Rabbit Model.
|
28212251 |
2017 |
|
Overactive bladder syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bladder biopsies from patients with bladder pain syndrome/interstitial cystitis, including 12 with and 19 without Hunner lesions, 13 with overactive bladder syndrome and 12 healthy controls, were analyzed by immunohistochemistry with antibodies to the nerve cell marker PGP9.5 (neuron-specific protein gene product 9.5), p75<sup>NTR</sup> (p75 neurotrophin receptor), the B-lymphocyte marker CD20 and mast cell tryptase.
|
27378135 |
2017 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of mast cell tryptase (MCT) in human pancreatic cancer angiogenesis is still not well documented.
|
27240355 |
2016 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of mast cell tryptase (MCT) in human pancreatic cancer angiogenesis is still not well documented.
|
27240355 |
2016 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study examined expression of PAR2 and endogenous proteinase activators (trypsin-2, mast cell tryptase) and proteinase inhibitors (serpin-A5, serpin-A13) in areas vulnerable and resistant to neurodegeneration in Parkinson's disease at different Braak α-synuclein stages of the disease in post-mortem brain.
|
25982926 |
2015 |