TARDBP, TAR DNA binding protein, 23435

N. diseases: 245; N. variants: 36
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE The TDP43/SRSF3 complex controls specific splicing events, including downstream genes <i>PAR3</i> and <i>NUMB</i> The effect of reduced metastasis and proliferation upon the knockdown of TDP43 or SRSF3 is mediated by the splicing regulation of <i>PAR3</i> and <i>NUMB</i> exon 12, respectively. 29581274 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE By silencing TDP-43, we saw significant inhibition of cell proliferation and metastasis in A375 and WM451 cells. 27786596 2017