BRD4, bromodomain containing 4, 23476

N. diseases: 335; N. variants: 6
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 AlteredExpression disease BEFREE JMJD6 has been reported to be over-expressed in oral, breast, lung, and colon cancers and plays important roles in regulation of transcription through interactions with transcription regulator BRD4, histones, U2AF65, Luc7L3, and SRSF11. 29176719 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 Biomarker disease CTD_human We found that BRD4 is critical for colon cancer proliferation, and its knockdown led to differentiation effects in vivo. 26752646 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 Biomarker disease BEFREE We found that BRD4 is critical for colon cancer proliferation, and its knockdown led to differentiation effects in vivo. 26752646 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 Biomarker disease BEFREE We used gastric and colon cancer cell lines to study the synergistic effect of As4S4 in combination with BRD4 inhibitor JQ1, or with chemotherapy drug cisplatin and irinotecan or with COX2 inhibitor celecoxib. 26586936 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 Biomarker disease BEFREE Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer. 22120039 2012