BRD4, bromodomain containing 4, 23476

N. diseases: 335; N. variants: 6
Disease: Glioblastoma Multiforme ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.330 Biomarker disease BEFREE In conclusion, these results suggest that Brd4 has great potential as a therapeutic target, and JQ1 has notable anti‑tumor effects against GBM which may be mediated via the VEGF/PI3K/AKT signaling pathway. 31485609 2019
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.330 Biomarker disease BEFREE The direct and indirect effects of µCAP on glioblastoma (U87MG-RedFluc) cancer cells were investigated in vitro<i>.</i> The results indicate that µCAP generates short- and long-lived species and radicals (i.e., hydroxyl radical (OH), hydrogen peroxide (H₂O₂), and nitrite (NO₂<sup>-</sup>), etc.) with increasing tumor cell death in a dose-dependent manner. 28555065 2017
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.330 Biomarker disease CTD_human BRD2 and BRD4, members of the BET family, are significantly increased in glioblastoma multiforme (GBM), the most common primary adult brain cancer. 27388964 2016
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.330 Biomarker disease CTD_human EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. 26455392 2015
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.330 AlteredExpression disease BEFREE Disruption of BRD4 expression in glioblastoma cells reduced cell cycle progression. 24496381 2014