CBX7, chromobox 7, 23492

N. diseases: 73; N. variants: 11
Disease: Glioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma 		0.030 AlteredExpression disease BEFREE In this study, we show that the invasive ability of glioma cells was decreased following CBX7 overexpression and CBX7 overexpression was associated with Wnt/β-catenin pathway inhibition, which also decreased downstream expression of ZEB1, a core epithelial-to-mesenchymal transition factor. 28388562 2017
CUI: C0017638
Disease: Glioma
Glioma 		0.030 AlteredExpression disease BEFREE We observed that decreased CBX7 protein levels enhanced glioma cells proliferation, migration and invasion. 28460453 2017
CUI: C0017638
Disease: Glioma
Glioma 		0.030 Biomarker disease BEFREE Thus, our study identifies Cbx7 as an inhibitor of glioma cell migration through its inhibitory effect on YAP/TAZ-CTGF-JNK signalling axis and underscores the importance of epigenetic inactivation of Cbx7 in gliomagenesis. 27291091 2016