CBX7, chromobox 7, 23492

N. diseases: 73; N. variants: 11
Disease: Thyroid carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.050 Biomarker disease BEFREE Loss of CBX7 expression has been described in several malignant neoplasias, including human colon and thyroid carcinomas proposing CBX7 as a tumor suppressor gene with a key role in cancer progression. 28259135 2017
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.050 AlteredExpression disease BEFREE We analyzed the gene expression profile of a thyroid carcinoma cell line after the restoration of CBX7 and, then, analyzed the transcriptional regulation of identified genes. 24865347 2014
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.050 AlteredExpression disease BEFREE We have previously shown that CBX7 expression is associated with a more malignant phenotype in thyroid cancer. 20542683 2010
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.050 AlteredExpression disease BEFREE Consistent with these data, we found a positive statistical correlation between CBX7 and E-cadherin expression in human thyroid carcinomas. 19706751 2009
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.050 AlteredExpression disease BEFREE In conclusion, loss of CBX7 expression correlates with a highly malignant phenotype in thyroid cancer patients. 18701502 2008