Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In spite of its limitations, our study details the intersection of systemic autoimmunity and CVID and provides valuable insights into these two groups of disorders.
|
29599028 |
2018 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CVID carrying biallelic-mutations had a low prevalence of autoimmunity in comparison with TACI wild-type CVID.
|
27123465 |
2016 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.
|
25505277 |
2015 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, compared with TA-Fc, 814-Fc showed two-fold inhibition effect on BLyS binding to TACI, suggesting that 814-Fc could inhibit BLyS bioactivity significantly and might serve as a potential antagonist to treat autoimmune diseases associated with BLyS overexpression.
|
25533501 |
2015 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Heterozygous C104R or A181E TNF receptor superfamily member 13b (TNFRSF13B) mutations impair removal of autoreactive B cells, weaken B-cell activation, and convey to patients with common variable immune deficiency (CVID) an increased risk for autoimmunity.
|
26100089 |
2015 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The impact of these abnormalities on T and B cell interaction may not only explain the immunodeficiency but also the development of autoimmunity in select groups of patients with CVID.
|
24747700 |
2014 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We aimed to focus on the state of the art of the relationship between infections, inflammation and autoimmunity in CVID.
|
23219764 |
2013 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Heterozygous mutations in the gene encoding the tumor necrosis factor receptor superfamily member TACI are associated with CVID and autoimmune manifestations, whereas two mutated alleles prevent autoimmunity.
|
24051380 |
2013 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data suggest a different impact of TACI mutations, from hypogammaglobulinemia in children to autoimmune disease in adulthood.
|
22697072 |
2012 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) mutations seem to be associated with autoimmunity and common variable immunodeficiency in humans.
|
21850030 |
2012 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Although signs of autoimmunity and lymphoproliferation are evident, the human phenotype differs from that of the Tnfrsf13b-/- mouse model.
|
16007087 |
2005 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.
|
12594954 |
2003 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The distribution of cases within families was compatible with autosomal recessive inheritance, making it plausible to test hypotheses about the disease risk of heterozygote carriers of putative CVID genes by comparing the frequency of autoimmune disorders and cancer in 1033 adult blood relatives to that in 566 spouse controls.
|
3957001 |
1986 |