leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified PRAME as a promising target antigen for adoptive leukemia therapy.
|
29738081 |
2018 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An afucosylated Fc form (Pr20M) directed antibody-dependent cellular cytotoxicity against PRAME+HLA-A2+ leukemia cells and was therapeutically effective against mouse xenograft models of human leukemia.
|
28628042 |
2017 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, it has found PRAME could be involved in the regulation of cell death in leukemias, but the mechanism of the function is unclear.
|
27049257 |
2016 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the leukemias expressing high levels of PRAME has favorable prognosis.
|
26823776 |
2015 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Previous studied has found that Preferentially Expressed Antigen of Melanoma (PRAME) is overexpressed in the leukemia cells, and knockdown of PRAME promoted apoptosis in leukemia K562 cells.
|
26744874 |
2015 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The preferentially expressed antigen of melanoma (PRAME) is known as a tumor-associated antigen, but its function in leukemia remains unclear.
|
21550659 |
2011 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, we decided to investigate the association of PRAME, EZH2 and TRAIL in BCR-ABL-positive leukemia.
|
20838376 |
2011 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.
|
20799951 |
2010 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We also demonstrated that PRAME overexpression induced the repression of three genes (Hsp27, S100A4 and p21) associated with an unfavorable prognosis in leukemia.
|
18452107 |
2008 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The above findings indicate that PRAME expression in acute leukemia does not seem to be of prognostic significance, whereas it might represent a candidate marker for the monitoring of minimal residual disease.
|
16860864 |
2007 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data confirm that PRAME quantification by real-time RT-PCR appears suitable for monitoring MRD in PRAME-positive leukaemia.
|
16681423 |
2006 |
leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.
|
16179254 |
2005 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The gene PRAME (preferentially expressed antigen of melanoma) was found to be expressed at high levels in a large fraction of different tumors and adult leukemias.
|
12419593 |
2002 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have screened 98 Japanese patients with leukaemia and lymphoma for expression of the PRAME gene using semiquantitative reverse transcription polymerase chain reaction (RT-PCR).
|
11298586 |
2001 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Remarkably, all acute myeloblastic leukaemias that carried the chromosomal translocation t(8;21), which fuses the genes AML1 and ETO, expressed PRAME at a high level.
|
9753074 |
1998 |