TNPO3, transportin 3, 23534

N. diseases: 66; N. variants: 25
Disease: HIV-1 infection ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.040 Biomarker disease BEFREE We analyzed the effect of TNPO3_mut on HIV-1 infection using PBMCs from patients with LGMD1F infected ex vivo. 31465518 2019
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.040 Biomarker disease BEFREE Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear import. 22398280 2012
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.040 Biomarker disease BEFREE To shed light on the mechanism by which TNPO3 contributes to HIV-1 infection we engineered a panel of twenty-seven single-cycle HIV-1 vectors each bearing a different CA mutation and characterized them for the ability to transduce cells in which TNPO3 had been knocked down (KD). 22145813 2011
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.040 Biomarker disease BEFREE We therefore conclude that capsid, not integrase, is the dominant viral factor that dictates transportin 3 dependency during HIV-1 infection. 19846519 2010