|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.
|
28548082 |
2017 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Hematocrit procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Hemoglobin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Functional studies revealed that HLF transactivates c-Jun to promote tumour initiating cell (TIC) generation and enhances TIC-like properties of hepatoma cells, thus driving HCC initiation and progression.
|
31118247 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
GBM tumors have elevated levels of METTL3 transcripts and silencing METTL3 in U87/TIC inhibited tumor growth in an intracranial orthotopic mouse model with prolonged mice survival.
|
28991227 |
2018 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
We present a simple method for genetic analysis, called touch imprint cytology combined with massively paralleled sequencing (touch imprint cytology [TIC]-seq), to detect somatic mutations in tumors.
|
27774772 |
2016 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Accordingly, tumors with low levels of EFA6B were enriched in the aggressive triple-negative and claudin-low breast cancer subtypes.
|
25115298 |
2014 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Using high-resolution array comparative genomic hybridization (aCGH), we profiled the copy number alterations in TIC genes using tumor DNA from frozen needle biopsies derived from 126 intermediate-risk patients who underwent IGRT.
|
22048240 |
2012 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
This implies that CD133 cannot be regarded as a CSC/TIC marker in all CRC cell lines and that functional measurements of tumor formation have to generally accompany CSC/TIC-directed mechanistic or therapeutic studies.
|
19699546 |
2009 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
TIC coexists with all forms of pelvic serous carcinoma and is a plausible origin for many of these tumors.
|
17255760 |
2007 |
|
Gilles de la Tourette syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings highlight a potential mechanism in Tourette syndrome through which heightened representation within insular cortex of embodied affective social information may impact the reactivity of subcortical motor pathways, supporting programmed motor actions that are causally implicated in tic generation.
|
30346484 |
2018 |
|
Gilles de la Tourette syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
The recent literature offers interesting clues that sharpen our understanding of comorbidities in Tourette disorder and thereby its clinical spectrum, offers insights into the cerebral networks underlying tic generation and cautiously announces personalized interventions for Tourette disorder patients based on their symptom profile.
|
29746399 |
2018 |
|
Gilles de la Tourette syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we describe the objectives and methods of the TIC Genetics study as a reference for future studies from our group and to facilitate collaboration between genetics consortia in the field of TS.
|
24771252 |
2015 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
We prepared FFPE tissues and TIC specimens from tumors in nine lung cancer patients and one patient with breast cancer.
|
27774772 |
2016 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We prepared FFPE tissues and TIC specimens from tumors in nine lung cancer patients and one patient with breast cancer.
|
27774772 |
2016 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results identify EFA6B as a novel antagonist in breast cancer and they point to its regulatory and signaling pathways as rational therapeutic targets in aggressive forms of this disease.
|
25115298 |
2014 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Transcriptomic and immunohistochemical analyses of human breast tumors revealed that the reduced expression of EFA6B was associated with loss of tight junction components and with increased signatures of EMT, cancer stemness, and poor prognosis.
|
25115298 |
2014 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results identify EFA6B as a novel antagonist in breast cancer and they point to its regulatory and signaling pathways as rational therapeutic targets in aggressive forms of this disease.
|
25115298 |
2014 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Transcriptomic and immunohistochemical analyses of human breast tumors revealed that the reduced expression of EFA6B was associated with loss of tight junction components and with increased signatures of EMT, cancer stemness, and poor prognosis.
|
25115298 |
2014 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The question of whether cancer stem/tumor-initiating cells (CSC/TIC) exist in human melanomas has arisen in the last few years.
|
22730244 |
2012 |
|
Tumor Initiation
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data indicate an essential role of the HH-GLI1 signaling in controlling self-renewal and tumor initiation of melanoma CSC/TIC.
|
22730244 |
2012 |
|
Tumor Initiation
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Co-injection of tumor-initiating cells with tumor-derived mesenchymal stem cells significantly increased tumor initiation compared to subcutaneous injection of TICs alone; co-injection also allowed tumor initiation with a single TIC.
|
22836804 |
2012 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The question of whether cancer stem/tumor-initiating cells (CSC/TIC) exist in human melanomas has arisen in the last few years.
|
22730244 |
2012 |
|
Carcinoma in situ of fallopian tube
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prophylactic salpingo-oophorectomies in BRCA+ women have recently identified the fimbria as a site of origin for early serous carcinoma (tubal intraepithelial carcinoma or TIC).
|
17255760 |
2007 |