Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the glioma-associated-oncogene (GLI) transcription factors, which activates the Hedgehog signalling pathway<sup>1,2</sup>.
|
31168089 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment with LINK-A locked nucleic acids or GPCR antagonists stabilized the PLC components, Rb and p53, and sensitized mammary gland tumors to immune checkpoint blockers.
|
31160797 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of YAP (Yes-associated protein 1) and MRTF-A (myocardin-related transcription factor A), two transcriptional co-activators regulated downstream of GPCRs (G protein-coupled receptors) and RhoA, in the growth of glioblastoma cells and in vivo glioblastoma multiforme (GBM) tumor development was explored using human glioblastoma cell lines and tumor-initiating cells derived from patient-derived xenografts (PDX).
|
29887596 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings are the first to identify a critical link between the tumor suppressor ARRDC3 and regulation of GPCR trafficking and signaling in breast cancer.
|
29348172 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest cells that stain positive for both LPAR3 and cancer stem cell markers are distinct from the tumor mass per se, and may mediate tumor invasiveness/expansion via LPA-LPAR3 signaling.
|
26701886 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Dysregulation of the JAK-STAT and GPCR pathways was also supported by gene expression profiling and further verified in patient tumor samples.
|
26854024 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrated that functional antibodies are invaluable tools for GPCR research and should open a new avenue for therapeutic treatment of tumors.
|
25832639 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although viral GPCRs are conserved in all gamma herpesviruses, kGPCR potently activated downstream signaling and induced tumor formation in nude mouse, whereas γHV68 GPCR failed to do so.
|
26107716 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Prometastatic GPCR CD97 is a direct target of tumor suppressor microRNA-126.
|
24274104 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RNA was extracted from tumor and normal tissues in 11 patients with SBNETs and 15 patients with PNETs, and qPCR was performed for 367 GPCR genes.
|
23158174 |
2012 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB, thus reducing expression of NF-kappaB-regulated tumor-promoting cytokines and growth factors.
|
22992343 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When SiHa cells with different receptor expression patterns were seeded on the backs of SCID mice, the resulting knockout of both LPA2 and LPA3 significantly attenuated tumor growth; this decrease in tumor growth was found to be linked with decreased angiogenesis (microvessel density), suggesting that LPA2 and LPA3 are crucial for in vivo tumor growth through an angiogenic mechanism.
|
21964883 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Raf kinase trapping to Golgi (RKTG) is a potential tumor suppressor gene due to its negative roles in regulating Ras/Raf/MEK/ERK (extracellular signal-regulated kinase) pathway and GPCR (G protein-coupled receptor) Gβγ subunit signaling.
|
21385899 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This overview summarizes expression database data as well as data from original research articles of adhesion-GPCRs in tumors.
|
21618830 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, the cellular mechanism that GPCR overexpression leads to tumor formation is largely unknown.
|
19408311 |
2009 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The percent survival of mice with tumors expressing LPA2 or LPA3 was reduced in comparison with animals with tumors expressing beta-galactosidase.
|
19001604 |
2008 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we conducted an in silico analysis of GPCR gene expression in primary human tumors by analyzing some publicly available gene expression profiling data.
|
16211229 |
2005 |