Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019100
Disease: Severe Dengue
Severe Dengue 		0.330 Therapeutic disease CTD_human Our observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV (either alone or complexed with an enhancing antibody) offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases. 18496526 2008
CUI: C0376300
Disease: Dengue Shock Syndrome
Dengue Shock Syndrome 		0.300 Therapeutic disease CTD_human Our observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV (either alone or complexed with an enhancing antibody) offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases. 18496526 2008
CUI: C0011311
Disease: Dengue Fever
Dengue Fever 		0.040 Biomarker disease LHGDN Moreover, anti-CLEC5A monoclonal antibodies inhibit DV-induced plasma leakage, as well as subcutaneous and vital-organ haemorrhaging, and reduce the mortality of DV infection by about 50% in STAT1-deficient mice. 18496526 2008
CUI: C0019100
Disease: Severe Dengue
Severe Dengue 		0.330 Biomarker disease BEFREE Through selective removal of gene expression data from the SVM model, we have identified seven genes (MYD88, TLR7, TLR3, MDA5, IRF3, IFN-alpha and CLEC5A) that may be central in differentiating DF patients from DHF, with MYD88 and TLR7 observed to be the most important. 20585645 2010
CUI: C0011311
Disease: Dengue Fever
Dengue Fever 		0.040 Biomarker disease BEFREE Through selective removal of gene expression data from the SVM model, we have identified seven genes (MYD88, TLR7, TLR3, MDA5, IRF3, IFN-alpha and CLEC5A) that may be central in differentiating DF patients from DHF, with MYD88 and TLR7 observed to be the most important. 20585645 2010
CUI: C0003864
Disease: Arthritis
Arthritis 		0.010 Biomarker disease BEFREE Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation. 20212065 2010
CUI: C0333307
Disease: Superficial ulcer
Superficial ulcer 		0.010 Biomarker disease BEFREE Here, we identify myeloid DAP12-associating lectin (MDL)-1 receptor (also known as CLEC5A) as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. 20212065 2010
CUI: C3887524
Disease: Skin Erosion
Skin Erosion 		0.010 Biomarker disease BEFREE Here, we identify myeloid DAP12-associating lectin (MDL)-1 receptor (also known as CLEC5A) as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. 20212065 2010
CUI: C2350521
Disease: Taste Perception (mental process)
Taste Perception (mental process) 		0.100 GeneticVariation phenotype GWASDB Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark. 22132133 2011
CUI: C0242966
Disease: Systemic Inflammatory Response Syndrome
Systemic Inflammatory Response Syndrome 		0.010 Biomarker disease BEFREE Targeting the MDL-1/Syk/PI3K/Akt/eNOS pathway represents a potential new therapeutic strategy to prevent the progression of SIRS to shock. 22005300 2011
CUI: C0019100
Disease: Severe Dengue
Severe Dengue 		0.330 GeneticVariation disease BEFREE We demonstrated that the TT genotype of CLEC5A SNP (rs1285933 C>T) is associated with dengue severity (OR=2.25; p=0.03) and that GG genotype of -336G>A DCSIGN (CD209) SNP is associated with protection to severe dengue (OR=0.12; p=0.04). 24016730 2013
CUI: C0011311
Disease: Dengue Fever
Dengue Fever 		0.040 Biomarker disease BEFREE Thus, DV can activate NLRP3 inflammasome via CLEC5A, and GM-Mϕ plays a more important role than M-Mϕ in the pathogenesis of DV infection. 23152543 2013
CUI: C0014057
Disease: Japanese Encephalitis
Japanese Encephalitis 		0.010 Biomarker disease BEFREE Moreover, up-regulation of pro-IL-1β, pro-IL-18, and NLRP3 associated with caspase-1 activation was observed in DV-infected GM-Mϕ, whereas blockade of CLEC5A/MDL-1, a C-type lectin critical for dengue hemorrhagic fever and Japanese encephalitis virus infection, inhibits NLRP3 inflammasome activation and pyrotopsis in GM-Mϕ. 23152543 2013
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.010 Biomarker group BEFREE Thus, ASXL1-MT–induced MDS-like disease in mice is associated with derepression of Hoxa9 and miR-125a and with Clec5a dysregulation. 24216483 2013
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 AlteredExpression disease BEFREE MDL-1 activator (Dengue virus type 2 antigen) stimulation on PBMCs resulted in significantly enhanced levels of proinflammatory cytokines in RA patients compared to those in OA patients or HC, indicating that MDL-1 activation is functional. 24465901 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.010 Biomarker disease BEFREE Frequencies of MDL-1-expressing monocytes in 22 active RA patients, 16 inactive RA patients, 12 osteoarthritis (OA) patients and 10 healthy controls (HC) were determined by flow-cytometry analysis. 24465901 2014
CUI: C0019100
Disease: Severe Dengue
Severe Dengue 		0.330 GeneticVariation disease BEFREE Here, we found that the TC genotype and T-carriers for SNP rs1285933 in the C-type lectin superfamily member 5 (CLEC5A) gene was associated with severe dengue in a Northern Brazilian population (OR=2.75 and p-value=0.01, OR=2.11 and p-value=0.04, respectively). 28764923 2017
CUI: C0011311
Disease: Dengue Fever
Dengue Fever 		0.040 GeneticVariation disease BEFREE Association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity and its functional effects. 28764923 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Thus, CLEC5A has a pivotal function in the activation of multiple aspects of innate immunity against bacterial invasion.The lectin receptor CLEC5A is a pattern recognition receptor that has been shown to detect dengue and Japanese encephalitis virus. 28824166 2017
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections 		0.010 Biomarker group BEFREE The role of MDL-1 in macrophage survival was further investigated by adenovirus infection and TUNEL assay. 29126450 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 AlteredExpression disease BEFREE In this study, we aimed to investigate the correlation between macrophage MDL-1 expression and early atherosclerosis progression. 29126450 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 AlteredExpression disease BEFREE In this study, we aimed to investigate the correlation between macrophage MDL-1 expression and early atherosclerosis progression. 29126450 2017
CUI: C0008373
Disease: Cholesteatoma
Cholesteatoma 		0.010 AlteredExpression disease BEFREE The levels of CLEC5A (C-type lectin domain family 5 member) and Dectin-1 mRNAs were significantly higher in cholesteatomas with ≥2 than ≤1 destroyed ossicles (p < 0.05), and the levels of MGL, Mincle, Dectin-1, and CLEC12B mRNAs were significantly higher in recurrent than initial cholesteatoma specimens (p < 0.05). 28440726 2017
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE Collectively, our results suggest that dampening CLEC5A-mediated inflammatory responses in myeloid cells reduces immunopathogenesis after influenza infections. 27795434 2017
CUI: C0023860
Disease: Listeriosis
Listeriosis 		0.010 Biomarker disease BEFREE CLEC5A is a critical receptor in innate immunity against Listeria infection. 28824166 2017