|
Severe Dengue
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Here, we found that the TC genotype and T-carriers for SNP rs1285933 in the C-type lectin superfamily member 5 (CLEC5A) gene was associated with severe dengue in a Northern Brazilian population (OR=2.75 and p-value=0.01, OR=2.11 and p-value=0.04, respectively).
|
28764923 |
2017 |
|
Severe Dengue
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated that the TT genotype of CLEC5A SNP (rs1285933 C>T) is associated with dengue severity (OR=2.25; p=0.03) and that GG genotype of -336G>A DCSIGN (CD209) SNP is associated with protection to severe dengue (OR=0.12; p=0.04).
|
24016730 |
2013 |
|
Severe Dengue
|
0.330 |
Biomarker
|
disease |
BEFREE |
Through selective removal of gene expression data from the SVM model, we have identified seven genes (MYD88, TLR7, TLR3, MDA5, IRF3, IFN-alpha and CLEC5A) that may be central in differentiating DF patients from DHF, with MYD88 and TLR7 observed to be the most important.
|
20585645 |
2010 |
|
Severe Dengue
|
0.330 |
Therapeutic
|
disease |
CTD_human |
Our observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV (either alone or complexed with an enhancing antibody) offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases.
|
18496526 |
2008 |
|
Dengue Shock Syndrome
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Our observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV (either alone or complexed with an enhancing antibody) offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases.
|
18496526 |
2008 |
|
Taste Perception (mental process)
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark.
|
22132133 |
2011 |
|
Dengue Fever
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity and its functional effects.
|
28764923 |
2017 |
|
Dengue Fever
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, DV can activate NLRP3 inflammasome via CLEC5A, and GM-Mϕ plays a more important role than M-Mϕ in the pathogenesis of DV infection.
|
23152543 |
2013 |
|
Dengue Fever
|
0.040 |
Biomarker
|
disease |
BEFREE |
Through selective removal of gene expression data from the SVM model, we have identified seven genes (MYD88, TLR7, TLR3, MDA5, IRF3, IFN-alpha and CLEC5A) that may be central in differentiating DF patients from DHF, with MYD88 and TLR7 observed to be the most important.
|
20585645 |
2010 |
|
Dengue Fever
|
0.040 |
Biomarker
|
disease |
LHGDN |
Moreover, anti-CLEC5A monoclonal antibodies inhibit DV-induced plasma leakage, as well as subcutaneous and vital-organ haemorrhaging, and reduce the mortality of DV infection by about 50% in STAT1-deficient mice.
|
18496526 |
2008 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that CLEC5A was highly upregulated in glioblastoma compared to normal brain tissues, which had an opposite relation with the overall patient survival.
|
30834619 |
2019 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma.
|
31591460 |
2019 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that CLEC5A was highly upregulated in glioblastoma compared to normal brain tissues, which had an opposite relation with the overall patient survival.
|
30834619 |
2019 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma.
|
31591460 |
2019 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that CLEC5A was highly upregulated in glioblastoma compared to normal brain tissues, which had an opposite relation with the overall patient survival.
|
30834619 |
2019 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma.
|
31591460 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In contrast, overexpression of CLEC5A stimulated cell proliferation, migration and invasion.
|
30834619 |
2019 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that CLEC5A was highly upregulated in glioblastoma compared to normal brain tissues, which had an opposite relation with the overall patient survival.
|
30834619 |
2019 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma.
|
31591460 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Thus, CLEC5A has a pivotal function in the activation of multiple aspects of innate immunity against bacterial invasion.The lectin receptor CLEC5A is a pattern recognition receptor that has been shown to detect dengue and Japanese encephalitis virus.
|
28824166 |
2017 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma.
|
31591460 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
CLEC5A has screened the gene related to OS metastasis, and CEBPB can be taken as TF regulating downstream gene CLEC5A.
|
31364785 |
2019 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLEC5A has screened the gene related to OS metastasis, and CEBPB can be taken as TF regulating downstream gene CLEC5A.
|
31364785 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The identification of critical roles of CLEC2 and CLEC5A/TLR2 in platelet-leukocyte interactions will support the development of novel strategies to treat acute viral infection in the future.
|
31160588 |
2019 |
|
Brain Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
C-type lectin domain family 5, member A (CLEC5A, MDL-1) promotes brain glioblastoma tumorigenesis by regulating PI3K/Akt signalling.
|
30834619 |
2019 |