Acute Promyelocytic Leukemia
|
0.320 |
Biomarker
|
disease |
BEFREE |
Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL.
|
28978663 |
2017 |
Acute Promyelocytic Leukemia
|
0.320 |
Biomarker
|
disease |
CTD_human |
Moreover, the silencing of <i>DAPK2</i> revealed that DAPK2 is an important downstream effector of p73 in ATO-induced apoptosis but not autophagy responses of APL cells.
|
28978663 |
2017 |
Acute Promyelocytic Leukemia
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
DAPK2 levels were restored in APL patients undergoing ATRA therapy.
|
24038216 |
2014 |
Hepatomegaly
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
|
28108177 |
2017 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alterations of genes encoding Sirt1, Mfn1 and Drp1 in an experimental model of AD suggest that modulation of mitochondria dynamics and Sirt1, including miRNA strategy, may be crucial for improvement of AD therapy.
|
31734880 |
2020 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are several PPIs which are current topics of research including Drp1, Aβ interactions with various targets including PrPC, Fyn kinase, NMDAR and mGluR5 and interaction of Mint2 with PDZ domain, etc., and thus have potential role in neurodegeneration and AD.
|
30836921 |
2019 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A similar ApoE4-driven decrease in DRP-1 was also observed in AD brains.
|
31306119 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, the scrib abrogated tumor showed the elevation of Drp-1 and reduced expression of Marf, which suggests enhanced mitochondrial-fission.
|
29360576 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results put forward a mechanism where COX-2 stimulates TFAM expression via p38-mediated DRP1/mitochondrial fragmentation signaling in irradiated tumor cells, which may be of value in understanding how to sensitize cancer cells during radiotherapy.
|
30862036 |
2019 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests that Drp1/Fis1 interaction and excessive mitochondrial fission greatly contribute to Aβ-mediated and AD-related neuropathology and cognitive decline.
|
29464060 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Migration and extravasation defects are also exhibited in Drp1-deficient mature T cells, unveiling its crucial role in controlling both T cell recirculation in secondary lymphoid organs and accumulation at tumor sites.
|
30540939 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer's disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities.
|
28854701 |
2017 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Drp1 activity and mitochondria fragmentation are significantly elevated in the brains of sporadic Alzheimer's disease (AD) cases.
|
28432138 |
2017 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The protective effect of Drp1 on the Aβ42 transgenic Drosophila was achieved by protecting the mitochondrial function, suggesting that Drp1 may be a potential therapeutic strategies for AD.
|
28531191 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activation of Drp1 with E2F5-mimetic peptide for inducing Drp1 mitochondrial localization enhanced ceramide-mediated mitophagy and led to tumor suppression in HPV-negative HNSCC-derived xenograft tumors in response to cisplatin in SCID mice.
|
28606997 |
2017 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on these findings, we hypothesize that a partial deficiency of Drp1 inhibits Drp1-Aβ interactions and protects Aβ-induced mitochondrial and synaptic toxicities, and maintains mitochondrial dynamics and neuronal function in AD neurons.
|
27677309 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, these findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1.
|
27889261 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas, Drp1 knockdown or treatment with mitochondrial division inhibitor-1 induced significant G1 phase arrest in HCC cells and reduced tumor growth in the xenotransplantation model.
|
27542250 |
2016 |
Platelet Component Distribution Width Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bax-PGAM5L-Drp1 complex is detected in arenobufagin and staurosporine treated CRC cells in vitro and in arenobufagin and cisplatin treated tumor in vivo as well.
|
26356820 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo findings confirmed that erucin-mediated inhibition of tumor growth in a breast cancer cell xenograft mouse model is associated with the mitochondrial translocation of cofilin and Drp1, fission and apoptosis.
|
25595902 |
2015 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.
|
25658205 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.
|
24038216 |
2014 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that aberrant S-nitrosylation of Drp1 is a prominent pathological feature of neurodegenerative diseases such as AD and HD.
|
23641925 |
2013 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.
|
20463395 |
2010 |