BACE1, beta-secretase 1, 23621

N. diseases: 120; N. variants: 8
Disease: Degenerative brain disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0154671
Disease: Degenerative brain disorder
Degenerative brain disorder 		0.010 Biomarker group BEFREE PF-06751979 is a selective inhibitor of the beta-site amyloid precursor protein cleaving enzyme-1, which is a key aspartyl protease in the generation of amyloid-β (Aβ) peptides, thought to be critical for the cerebral degeneration observed in Alzheimer's disease. 31424395 2019