Alzheimer Disease, Late Onset
|
0.390 |
Biomarker
|
disease |
BEFREE |
Additional studies are needed to confirm the usefulness of BACE1, alone or in combination with other markers, in discriminating patients and predicting LOAD onset and progression.
|
31745860 |
2020 |
Alzheimer Disease, Late Onset
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Abbreviations: Alzheimer's disease (AD); Late-onset Alzheimer's disease (LOAD); Early-onset Alzheimer's disease (EOAD); Shugoshin-1 (Sgo1); Chromosome Instability (CIN); apolipoprotein (Apoe); Central nervous system (CNS); Amyloid precursor protein (APP); N-methyl-d-aspartate (NMDA); Hazard ratio (HR); Cyclin-dependent kinase (CDK); Chronic Atrial Intestinal Dysrhythmia (CAID); beta-secretase 1 (BACE); phosphor-Histone H3 (p-H3); Research and development (R&D); Non-steroidal anti-inflammatory drugs (NSAIDs); Brain blood barrier (BBB).
|
30231670 |
2018 |
Alzheimer Disease, Late Onset
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Our findings provide a mechanistic role of BIN1 in the pathogenesis of AD as a novel genetic regulator of BACE1 levels and Aβ production.
|
27179792 |
2016 |
Alzheimer Disease, Late Onset
|
0.390 |
Biomarker
|
disease |
BEFREE |
We collected blood DNA from 120 late-onset Alzheimer's disease (AD) patients and 115 healthy matched controls and analysed the methylation levels of genes involved in amyloid-beta peptide production (PSEN1 and BACE1), in DNA methylation (DNMT1, DNMT3A and DNMT3B), and in one-carbon metabolism (MTHFR), searching for correlation with age and gender, with biomarkers of one-carbon metabolism (plasma homocysteine, and serum folate and vitamin B12 levels), and with disease status (being healthy or having AD).
|
26079324 |
2015 |
Alzheimer Disease, Late Onset
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
|
23750206 |
2013 |
Alzheimer Disease, Late Onset
|
0.390 |
Biomarker
|
disease |
BEFREE |
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
|
17098871 |
2006 |
Alzheimer Disease, Late Onset
|
0.390 |
Biomarker
|
disease |
CTD_human |
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
|
16407166 |
2006 |
Alzheimer Disease, Late Onset
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that BACE1 gene polymorphism C786G might act as an APOE epsilon4 allele-dependent risk factor for developing LOAD in Chinese.
|
15784960 |
2005 |
Alzheimer Disease, Late Onset
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers.
|
12707937 |
2003 |
Alzheimer Disease, Late Onset
|
0.390 |
Biomarker
|
disease |
BEFREE |
The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.
|
11234778 |
2001 |