Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
Delivery of BACE1 siRNA mediated by TARBP-BTP fusion protein reduces β-amyloid deposits in a transgenic mouse model of Alzheimer's disease.
|
30837353 |
2019 |
Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
Excess Aβ production by the key protease BACE1, results in Aβ aggregation, forming amyloid plaques, all of which contribute to the pathogenesis of Alzheimer's disease.
|
30842555 |
2019 |
Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
BACE1 was inhibited, thereby reducing amyloid plaques (Aβ) deposition and eventually reducing inflammation and apoptosis of neurons as revealed by immunohistopathological examination.
|
31276550 |
2019 |
Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
Transcript levels of the genes associated with loss of synaptic plasticity (Bdnf, Syn, GluN1, α7-nAChR, and M<sub>1</sub>-mAChR), formation of neurofibrillary tangles (Tau4 and Tau3), and amyloid plaques (App, Adam10, and Bace1), in the hippocampus of rats at 0, 1, 3, 6, and 9 days after ODX (D<sub>0</sub>, D<sub>1</sub>, D<sub>3</sub>, D<sub>6</sub> and D<sub>9</sub>, respectively) were determined.
|
31114953 |
2019 |
Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
The β-site amyloid cleavage enzyme 1 (BACE1) is the major constituent of amyloid plaques and plays a central role in this brain pathogenesis, thus it constitutes an auspicious pharmacological target for its treatment.
|
31235739 |
2019 |
Plaque, Amyloid
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In APP/PS1 transgenic mice, the nanocomplexes significantly decrease BACE1 mRNA and the amyloid plaques, suppress phosphorylated tau protein levels, as well as promote hippocampal neurogenesis.
|
29679667 |
2018 |
Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
Coimmunostaining results showed BACE-1 surrounded amyloid plaques in brain sections.
|
27294139 |
2016 |
Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
Targeting BACE1 (β-site APP cleaving enzyme 1 or β-secretase) is the focus of Alzheimer's disease (AD) research because this aspartyl protease is involved in the abnormal production of β amyloid plaques (Aβ), the hallmark of its pathophysiology.
|
22926063 |
2012 |
Plaque, Amyloid
|
0.090 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that amyloid plaques induce BACE1 in surrounding neurons at early stages of pathology before neuron death occurs.
|
17409228 |
2007 |