|
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, NPM/ALK transcripts were not detected in any of the 34 cases of HD or in the 19 cases of T-NHL.
|
7662979 |
1995 |
|
Immunologic Deficiency Syndromes
|
0.020 |
GeneticVariation
|
group |
BEFREE |
NPM/ALK fusion transcripts were found in 11 of 17 (65%) classical ALCL cases but were not detected in the four primary cutaneous cases of ALCL or in the three HIV-related ALCL cases.
|
7662979 |
1995 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have developed a PCT methodology which has enabled the detection of the NPM-ALK rearrangements amongst seven t(2;5)(p23;q35) ALCL cases based on a long-range PCR of genomic DNA.
|
7772531 |
1995 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The NPM/ALK-expressing cases were not confined to NHLs with anaplastic morphology and included 15 ALCLs, 6 immunoblastic lymphomas, and 10 diffuse large-cell lymphomas.
|
7780128 |
1995 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To better define the spectrum of lymphomas that contain this translocation, we have analyzed 70 cases of non-Hodgkin's lymphoma (NHL) for expression of the t(2;5)-derived NPM/ALK chimeric message by reverse transcriptase-polymerase chain reaction (RT-PCR).
|
7780128 |
1995 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NPM/ALK-expressing cases were not confined to NHLs with anaplastic morphology and included 15 ALCLs, 6 immunoblastic lymphomas, and 10 diffuse large-cell lymphomas.
|
7780128 |
1995 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas.
|
8122112 |
1994 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
|
8122112 |
1994 |
|
Adult Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
|
8122112 |
1994 |
|
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
|
8122112 |
1994 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
|
8122112 |
1994 |
|
Malignant transformation
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas.
|
8122112 |
1994 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As all seven bona fide HD cell lines were NPM-ALK-negative, these results do not support the notion that the t(2;5) represents a chromosomal aberration common to both ALCL and HD.
|
8558920 |
1996 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data show that NPM-ALK gene transcripts are identified in a subpopulation of ALCL, almost exclusively in T or null cell in origin, and in rare cases of HD.
|
8562933 |
1996 |
|
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overall, 6 (3 T and 3 null) of 49 ALCL and 3 (2 nodular sclerosis and 1 mixed cellularity) of 72 HD showed the presence of NPM-ALK transcripts by RT-PCR.
|
8562933 |
1996 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The NPM sequences contained in the shorter NPM-RAR cDNA are identical to the NPM sequences contained in the NPM-ALK fusion gene expressed in t(2;5) lymphomas.
|
8562957 |
1996 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
NPM/ALK gene fusion transcripts identify a distinct subgroup of null type Ki-1 positive anaplastic large cell lymphomas.
|
8616079 |
1996 |
|
Malignant histiocytosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The specific translocation was found exclusively in six childhood tumours previously diagnosed as malignant histiocytosis (MH), whereas all adult lymphomas (three ALCL without characteristics of MH, three secondary ALCL following HD) and two paediatric cases of secondary ALCL following HD did not show NPM/ALK gene fusion products.
|
8616079 |
1996 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The expected 177 bp product indicative of the NPM-ALK rearrangement was identified in Karpas 299 and SUDHL-1 cell lines and in two out of eight ALCLs.
|
8683377 |
1996 |
|
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of the NPM-ALK rearrangement in Hodgkin's disease.
|
8683377 |
1996 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In order to check this hypothesis, reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to detect the hybrid NPM-ALK gene in 30 tumour samples, including 22 lymph node biopsies from HD and eight ALCL specimens.
|
8683377 |
1996 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
All NPM-ALK-positive lymphomas and 1 NPM-ALK-positive LP exhibited a clonal rearrangement of the T cell receptor gamma-chain gene.
|
8701987 |
1996 |
|
Lymphomatoid Papulosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
All NPM-ALK-positive lymphomas and 1 NPM-ALK-positive LP exhibited a clonal rearrangement of the T cell receptor gamma-chain gene.
|
8701987 |
1996 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site.
|
8721682 |
1996 |
|
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lack of the t(2;5) or other mutations resulting in expression of anaplastic lymphoma kinase catalytic domain in CD30+ primary cutaneous lymphoproliferative disorders and Hodgkin's disease.
|
8781433 |
1996 |