Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALK(-) CD30(+) anaplastic large cell lymphoma is a type of non-Hodgkin lymphoma showing poor prognosis, and seldom co-occurs with sarcoidosis.
|
30909793 |
2019 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease.
|
29905579 |
2018 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma.
|
29758012 |
2018 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Systemic anaplastic lymphoma kinase positive (ALK+) anaplastic large cell lymphoma with extranodal involvement (ALCL-E) is a rare form of non-Hodgkin lymphoma.
|
29602182 |
2018 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma.
|
29035291 |
2017 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a rare distinct type of non-Hodgkin's lymphoma that arises in association with alterations of the ALK gene.
|
27686567 |
2017 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, ALK was initially discovered as the fusion gene in anaplastic large cell non-Hodgkin lymphoma, a disease predominantly of childhood.
|
26503946 |
2016 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase (ALK) has emerged as an important oncogene in a number of human malignancies ranging from non-Hodgkin lymphoma to neuroblastoma.
|
22086496 |
2013 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) is an uncommon non-Hodgkin's lymphoma of T-cell origin, the majority of which express CD4 and show frequent pan-T-cell antigen loss.
|
21763080 |
2011 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, initially identified through the analysis of a specific translocation associated with a rare subtype of non-Hodgkin's lymphoma.
|
21205076 |
2011 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All 375 patients with systemic ALK-positive ALCL included in an international trial launched by the European Intergroup for Childhood Non-Hodgkin's Lymphoma were reviewed by an international panel of pathologists based on conventional hematoxylin and eosin-stained and immunostained sections and classified according to the 2001 WHO classification.
|
22084369 |
2011 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we show that the anaplastic lymphoma kinase (ALK), originally identified as a fusion kinase in a subtype of non-Hodgkin's lymphoma (NPM-ALK) and more recently in adenocarcinoma of lung (EML4-ALK), is also a frequent target of genetic alteration in advanced neuroblastoma.
|
18923524 |
2008 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
|
9174053 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NPM-ALK fusion gene, formed by the t(2;5)(p23;q35) translocation in non-Hodgkin's lymphoma, encodes a 75-kDa hybrid protein that contains the amino-terminal 117 amino acid residues of the nucleolar phosphoprotein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK (anaplastic lymphoma kinase).
|
9121481 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of the t(2;5)(p23;q35) and NPM-ALK fusion in non-Hodgkin's lymphoma by two-color fluorescence in situ hybridization.
|
9057650 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
|
8122112 |
1994 |