Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activation of IGF-1R pathway and NPM-ALK G1269A mutation confer resistance to crizotinib treatment in NPM-ALK positive lymphoma.
|
31177400 |
2019 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vaccination with ALK DNA led to protection against lymphoma growth in a murine model.
|
29642597 |
2018 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma.
|
29905579 |
2018 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
By comparing sweyjawbu transcript levels, it was possible to discriminate 12 ALK rearrangement-positive lymphoma samples from 64 ALK rearrangement-negative lymphomas.
|
27974674 |
2017 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (LBCL) is a rare lymphoma subtype.
|
28693234 |
2017 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, aberrantly expressed ALK is involved in the pathogenesis of diverse malignancies, including distinct types of lymphoma, lung carcinoma, and neuroblastoma.
|
27879258 |
2017 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed a specific synergistic effect of combining ALK inhibitors with an mTOR inhibitor (temsirolimus), in ALK+ lymphoma cells.
|
27662658 |
2016 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, antagonizing SUMOylation by the SENP1 protease decreased the accumulation of NPM-ALK and suppressed lymphoma cell viability, proliferation, and anchorage-independent colony formation.
|
26476082 |
2015 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas ALK-fusion proteins are common in lymphoma and lung cancer, there are few reports of ALK rearrangements in NB indicating that ALK mainly exerts its oncogenic capacity via activating mutations and/or overexpression in this tumor type.
|
25251827 |
2015 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Once a diagnosis of lymphoma is established, it is important to exclude systemic anaplastic lymphoma kinase-negative ALCL involving the breast, primary cutaneous ALCL, and other CD30(+) lymphoproliferative disorders.
|
24878027 |
2014 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data argue against PDGFRB activation in association with ALK gene aberrations in metastatic NSCLC and thus seem to imply differential pathobiological roles of ALK alterations in lung cancer and lymphoma, possibly depending on different fusion partner genes.
|
24750504 |
2014 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested the hypothesis that iNOS is deregulated in NPM-ALK(+) T-cell lymphoma and promotes the survival of this lymphoma.
|
23338972 |
2013 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway.
|
21518927 |
2011 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings represent the first recurrent translocation reported in ALK-negative ALCL and highlight the utility of massively parallel genomic sequencing to discover novel translocations in lymphoma and other cancers.
|
21030553 |
2011 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we used conditional onco-ALK (NPM-ALK and TPM3-ALK) mouse MEF cell lines (ALK+ fibroblasts) and transgenic models (ALK+ B-lymphoma) to investigate the involvement and regulation of angiogenesis in ALK tumor development.
|
21778999 |
2011 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALK positive diffuse large B-cell lymphomas (DLBCL) are a distinct lymphoma subtype associated with a poor outcome.
|
21494621 |
2011 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our results show (1) that NPM-ALK and TPM3-ALK oncogenes are sufficient for lymphoma/leukemia development and required for tumor maintenance, hence validating ALK as potentially effective therapeutic target; and (2) for the first time, in vivo, the equal tumorigenic potential of the NPM-ALK and TPM3-ALK oncogenic tyrosine kinases.
|
20223922 |
2010 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma.
|
19965671 |
2010 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer.
|
20624322 |
2010 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Except in ALK-positive anaplastic large cell lymphoma, defined by ALK gene fusions, chromosomal translocations are otherwise rare in PTCLs, but some recurrent rearrangements might be associated with distinct lymphoma subtypes.
|
19233683 |
2009 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Diffuse large B-cell lymphoma (DLBCL) with plasmablastic features associated with t(2;17)(p23;q23) and characteristic granular cytoplasmic anaplastic lymphoma kinase-1 (ALK1) protein expression is a rare lymphoma subtype.
|
19521280 |
2009 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, they suggest that future immunotherapeutic protocols for this type of lymphoma may need to include the inhibition of NPM/ALK and STAT3 to achieve optimal clinical efficacy.
|
19088198 |
2008 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case is the first reported occurrence of a primary meningeal ALK lymphoma in a child.
|
19131793 |
2008 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No such "signalosome" is found in rafts of ALK(+) T lymphoma and Hodgkin-derived cell lines, despite similar Cbp/PAG, Lyn, and STAT3 expression and similar amounts of raft sphingolipids.
|
18070987 |
2008 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Anaplastic large cell lymphoma (ALCL) is an aggressive T-lineage lymphoma harboring chromosomal translocations involving the anaplastic lymphoma kinase (ALK) tyrosine kinase.
|
16785248 |
2006 |