ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Disease: HER2 gene amplification ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.050 Biomarker disease BEFREE HER2 amplification and ALK/EML4 fusion were assessed by fluorescence in situ hybridization. 30734108 2019
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.050 Biomarker disease BEFREE Its utility has been reported in HER2 amplification of breast and gastric carcinoma and ALK-rearranged lung cancer. 28735509 2017
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.050 GeneticVariation disease BEFREE Mutations of EGFR, KRAS, BRAF, AKT1, PIK3CA and HER2 were assessed by pyrosequencing; HER2 amplification and ALK translocation were assessed by fluorescence in situ hybridization. 26028668 2015
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.050 Biomarker disease BEFREE The most prevalent biomarkers in pulmonary adenocarcinoma were KRAS mutations (29%), loss of PTEN expression (18%), EGFR mutations (9%), HER2 amplification (5%) and BRAF mutations (3%), while the prevalence of ALK translocations and PIK3CA mutations was extremely low. 23876834 2013
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.050 GeneticVariation disease BEFREE ALK rearrangements and HER2 amplification were assessed by FISH. 22761469 2012