|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In recent years, there has been substantial research evaluating the relationship between arachidonate 5-lipoxygenase-activating protein (<i>ALOX5AP</i>) polymorphisms and ischemic stroke (IS).
|
30774347 |
2019 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Allele-specific methylation contributed by CpG-SNP is associated with regulation of ALOX5AP gene expression in ischemic stroke.
|
30003372 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study found that ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians.
|
29096760 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Generalized multifactor dimensionality reduction (GMDR) analysis revealed that the combination of ALOX5 rs10900213, ALOX5AP rs4293222 and MPO rs2107545 was significantly associated with increased risk of ischemic stroke (P=0.0040, OR (95% CI) =1.991 (1.241 to 3.195)).
|
29041000 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present meta-analysis suggested that the A allele at the ALOX5AP SG13S114 polymorphism is a protective factor for the IS in the Europeans.
|
28101761 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A two-stage study design was used to explore the relationship between variants in the transcriptional regulatory region of ALOX5AP gene and ischemic stroke (IS) risk in Chinese populations.IS was determined using CT and/or MRI.
|
27416969 |
2016 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings support the association of the epistatic interactions of ALOX5AP, THBD, and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility, suggesting a modulation of stroke risk by a genetic main effect and gene-gene interactions.
|
26159646 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.
|
25534367 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the association between the risk of ischemic stroke and single-nucleotide polymorphisms (SNPs) in the ALOX5AP and PDE4D genes in a southeastern Chinese population.
|
24485247 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP gene is associated with decreased risk of ischemic stroke in two independent Chinese populations.
|
25815512 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no statistically significant association of ALOX5AP rs4073259 SNP with ischemic stroke in this northeastern Chinese Han population living in Heilongjiang province, China.
|
24635928 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ALOX5AP SG13S114 polymorphism is associated with susceptibility to IS in Chinese population.
|
24148560 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, combined analysis indicated that AA genotype of ALOX5AP SG13S114A/T was significantly associated with increased risk of IS incidence compared with TT genotype [OR and 95%CI: 1.47 (1.13-1.91), P=0.005].
|
24183033 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To conclude, SG13S114/AA of the ALOX5AP gene was associated with an increased risk for IS.
|
24198186 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest the ALOX5AP SNP A allele in rs4073259 and genotype rs9579646 GG, rs9551963 AC, and haplotype rs9315050 & rs9551963 AAAC were associated with an increased risk of ischemic stroke in the Han population, while rs4073259 GG was associated with a decreased risk.
|
22849376 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In combined analysis of multiple genes and loci, individuals with ALOX5AP rs12429692 T allele, ALOX5 rs2029253 A allele, and LTA4H rs6538697 C allele suggested a significantly increased susceptibility to IS (adjusted OR, 1.70; 95% CI, 1.07-2.69; P=0.024).
|
23079278 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR).
|
21816595 |
2011 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated genetic variants in the promoter region of the ALOX5AP gene and the association with ischemic stroke in a north Chinese Han population.
|
21893978 |
2011 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A first meta-analysis of both subsets showed that the T allele of the SG13S114 SNP in ALOX5AP was a risk factor for IS after Bonferroni correction [OR = 1.22 (1.06-1.40); p = 0.006].
|
20357438 |
2010 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we found no evidence of association between PDE4D and ALOX5AP genes and the risk of IS in a genetically homogenous population from Sardinia.
|
19417766 |
2009 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the association of common genetic variation in prostaglandin H synthase 1 (PTGS1), prostaglandin H synthase 2 (PTGS2), thromboxane A2 synthase (TBXAS1), prostacyclin synthase (PTGIS), prostaglandin E synthase (PTGES), 5-lipoxygenase activating protein (ALOX5AP), 12-lipoxygenase (ALOX12) and 15-lipoxygenase (ALOX15) with the risks of myocardial infarction (MI) and ischemic stroke.
|
19046748 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous Icelandic studies reported that single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) region and the 5-lipoxygenase activating protein ALOX5AP were associated with ischaemic stroke, whereas other studies reported ambiguous findings.
|
18398440 |
2008 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we report significant association of variants of ALOX5AP with ischemic stroke and ischemic stroke subtypes among whites.
|
17387518 |
2007 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 10 specific Icelandic ALOX5AP gene variants among 600 male participants with incident atherothrombotic events (myocardial infarction [MI] or ischemic stroke) and among 600 age- and smoking-matched male participants, all white, who remained free of reported cardiovascular disease during follow-up within the Physicians' Health Study cohort.
|
16778124 |
2006 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To further assess the contribution of the ALOX5AP variants to cardiovascular diseases in a population outside Iceland, we genotyped seven single-nucleotide polymorphisms that define both HapA and HapB from 450 patients with ischemic stroke and 710 controls from Aberdeenshire, Scotland.
|
15640973 |
2005 |