|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We find that embryonic stem cells genetically depleted of KIF4 support anchorage-independent growth and form tumors in nude mice.
|
16890532 |
2006 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The active movement of Kif4 participates in several cellular functions, including DNA repair, mitosis, the transport of macromolecules, survival of neurons and even tumorigenesis and progression.
|
31486502 |
2019 |
|
Malignant neoplasm of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.
|
29204984 |
2018 |
|
Carcinoma of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.
|
29204984 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In addition, Transwell analysis indicated that KIF4A promotes migration and invasion in CRC.
|
29706624 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
KIF4A had a strong prognostic value in both ER-positive and ER-negative breast cancers comparable to or even better than tumor size, lymph node invasion, and Elston grade.
|
30127624 |
2018 |
|
Primary malignant neoplasm of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.
|
29204984 |
2018 |
|
Malignant neoplasm of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis.
|
28160558 |
2017 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
During cell division, PHF14 directly bound to and co-localized with KIF4A (a nuclear motor protein involved in lung carcinogenesis) to form a functional complex.
|
28160558 |
2017 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
However, linkage between Kif4A and infiltrating macrophages in tumorigenesis and progression remains unclear.
|
28533507 |
2017 |
|
Carcinoma of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis.
|
28160558 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
KIF4A siRNA transfection was performed to investigate its role in fucoidan-modulated OSCC cells invasion.
|
28004293 |
2017 |
|
Primary malignant neoplasm of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis.
|
28160558 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
FKBP14 knockdown decreased the protein levels of PCNA, CDK1 and CCNB1 that promotes cell cycle, increased Bax, caspase-3 and caspase-7 protein involved in promoting cell apoptosis, and increased KIF4A expression as well as decreased SMC4 and TMEM33 proteins that contribute to cell invasion and adhesion.
|
27223089 |
2016 |
|
Malignant neoplasm of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Kinesin family member 4A (KIF4A) is a microtubule‑based motor protein, which is upregulated in cervical and lung cancer.
|
25998931 |
2015 |
|
Carcinoma of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Kinesin family member 4A (KIF4A) is a microtubule‑based motor protein, which is upregulated in cervical and lung cancer.
|
25998931 |
2015 |
|
Primary malignant neoplasm of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Kinesin family member 4A (KIF4A) is a microtubule‑based motor protein, which is upregulated in cervical and lung cancer.
|
25998931 |
2015 |
|
Malignant neoplasm of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Treatment of lung cancer cells with small interfering RNAs for KIF4A suppressed growth of the cancer cells.
|
18006763 |
2007 |
|
Carcinoma of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Treatment of lung cancer cells with small interfering RNAs for KIF4A suppressed growth of the cancer cells.
|
18006763 |
2007 |
|
Primary malignant neoplasm of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Treatment of lung cancer cells with small interfering RNAs for KIF4A suppressed growth of the cancer cells.
|
18006763 |
2007 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Here, we have taken advantage of the direct formation of aneuploidy in the absence of KIF4 to determine whether loss of a molecular motor and generation of aneuploidy during mitosis can trigger tumorigenesis.
|
16890532 |
2006 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The expression levels of KIF4A have been investigated in numerous types of cancer, including cervical, lung, oral, and breast cancer, and are established to be associated with poor patient prognosis.
|
29434924 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Therefore KIF4 has potential as a therapeutic target for cancer therapy.
|
30081192 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
|
29706624 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Therefore KIF4 has potential as a therapeutic target for cancer therapy.
|
30081192 |
2018 |