|
Intellectual Disability
|
0.410 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Our results suggest that mutations in KIF4A and KIF5C cause ID by tipping the balance between excitatory and inhibitory synaptic excitability.
|
24812067 |
2014 |
|
Intellectual Disability
|
0.410 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that mutations in KIF4A and KIF5C cause ID by tipping the balance between excitatory and inhibitory synaptic excitability.
|
24812067 |
2014 |
|
Intellectual Disability
|
0.410 |
Biomarker
|
group |
HPO |
|
|
|
|
MENTAL RETARDATION, X-LINKED 100
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
MENTAL RETARDATION, X-LINKED 100
|
0.400 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
MENTAL RETARDATION, X-LINKED 100
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Liver carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
A xenograft mouse model was used to explore the regulatory effect of FOXM1-KIF4A axis on HCC tumor growth.
|
31072351 |
2019 |
|
Liver carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
Totally, 427 upregulated (e.g., cell division cycle associated 5 [<i>CDCA5</i>], kinesin family member 4A [<i>KIF4A</i>], TPX2 microtubule nucleation factor [<i>TPX2</i>]) and 313 downregulated (e.g., metallothionein 1E [<i>MT1E</i>]) DEGs were identified in HCC.
|
31593490 |
2019 |
|
Liver carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
TOP2A, CCNB1, and KIF4A might promote the development of HCC, especially in proliferation and differentiation, which could be novel biomarkers and targets for diagnosis and treatment of HCC.
|
29977454 |
2018 |
|
Liver carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
Taken together, KIF4A may act as a prognostic biomarker and potential therapeutic target in human HCC.
|
29396392 |
2018 |
|
Liver carcinoma
|
0.360 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
In summary, our work identified KIF4A as a potential predictive and prognostic marker for hepatocellular carcinoma.
|
28646197 |
2017 |
|
Liver carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that the expression of KIF4A was significantly higher in the HCC tissues than in the paracancerous tissues.
|
25998931 |
2015 |
|
Hydrocephalus
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Seizures
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Agenesis of corpus callosum
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Dysmorphic facies
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
X- linked recessive
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Poor speech
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Dilated ventricles (finding)
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Multicystic Dysplastic Kidney
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Patients with lower tumor KIF4A expression had improved overall survival (OS) and disease-free survival (DFS).
|
31796514 |
2020 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
KIF4A had a strong prognostic value in both ER-positive and ER-negative breast cancers comparable to or even better than tumor size, lymph node invasion, and Elston grade.
|
30127624 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The expression level of KIF4A in tumor tissue is significantly associated with the survival time, and a significant correlation between KIF4A expression and clinical information stage, metastasis and tumor dimension was observed.
|
28646197 |
2017 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Tumor tissue microarray was applied to examine the expression of KIF4A protein and its clinicopathologic significance in archival non-small cell lung cancer (NSCLC) samples from 357 patients.
|
18006763 |
2007 |