|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gene Set Enrichment Analysis (GSEA) revealed that high mRNA expression of KIF4A, 18A, and 23 in LGG and GBM patients showed significant positive correlations with the cell cycle, E2F targets, G<sub>2</sub>M checkpoint, Myc target, and mitotic spindle.
|
30872592 |
2019 |
|
Low grade glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gene Set Enrichment Analysis (GSEA) revealed that high mRNA expression of KIF4A, 18A, and 23 in LGG and GBM patients showed significant positive correlations with the cell cycle, E2F targets, G<sub>2</sub>M checkpoint, Myc target, and mitotic spindle.
|
30872592 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA (ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC.
|
30744636 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA (ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC.
|
30744636 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Moreover, the misregulation of KIF4 is related to viral infection and neural system diseases like Alzheimer.
|
30081192 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, our results shed light on a potential mechanism in that motor protein KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane.
|
29204984 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
|
29434924 |
2018 |
|
Multiple malignancy
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Besides, study based on TCGA cohorts also reveals high KIF4A mRNA expression are significantly associated with shorter overall survival in multiple cancer types.
|
28646197 |
2017 |
|
Tumor Initiation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Gene sets enrichment analysis exhibited that cell cycle related pathways and p53 signaling pathways to be top altered pathways of in KIF4A-high expression group in HCC, suggesting the potential role of KIF4A in mediating tumor initiation and progression.
|
28646197 |
2017 |
|
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the expression profiles of KIF4A were examined in cancerous tissues and paracancerous tissues from patients with HCC, who presented with histories of chronic HBV infection, and the role of HBV in the induction of the expression of KIF4A was investigated.
|
25998931 |
2015 |
|
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
|
24386490 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
|
24386490 |
2013 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Positive immunostaining of KIF4A protein was associated with male gender (P = 0.0287), nonadenocarcinoma histology (P = 0.0097), and shorter survival for patients with NSCLC (P = 0.0005), and multivariate analysis confirmed its independent prognostic value (P = 0.0012).
|
18006763 |
2007 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This analysis exhibited frequent and robust upregulated expression in CC relative to normal cervix for genes EPHB2 (1p36), CDCA8 (1p34.3), AIM2 (1q22-23), RFC4, MUC4, and HRASLS (3q27-29), SKP2 (5p12-13), CENTD3 (5q31.3), PTK2, RECQL4 (8q24), MMP1 and MMP13 (11q22.2), AKT1 (14q32.3), ABCC3 (17q21-22), SMARCA4 (19p13.3) LIG1 (19q13.3), UBE2C (20q13.1), SMC1L1 (Xp11), KIF4A (Xq12), TMSNB (Xq22), and CSAG2 (Xq28).
|
17243165 |
2007 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This analysis exhibited frequent and robust upregulated expression in CC relative to normal cervix for genes EPHB2 (1p36), CDCA8 (1p34.3), AIM2 (1q22-23), RFC4, MUC4, and HRASLS (3q27-29), SKP2 (5p12-13), CENTD3 (5q31.3), PTK2, RECQL4 (8q24), MMP1 and MMP13 (11q22.2), AKT1 (14q32.3), ABCC3 (17q21-22), SMARCA4 (19p13.3) LIG1 (19q13.3), UBE2C (20q13.1), SMC1L1 (Xp11), KIF4A (Xq12), TMSNB (Xq22), and CSAG2 (Xq28).
|
17243165 |
2007 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This analysis exhibited frequent and robust upregulated expression in CC relative to normal cervix for genes EPHB2 (1p36), CDCA8 (1p34.3), AIM2 (1q22-23), RFC4, MUC4, and HRASLS (3q27-29), SKP2 (5p12-13), CENTD3 (5q31.3), PTK2, RECQL4 (8q24), MMP1 and MMP13 (11q22.2), AKT1 (14q32.3), ABCC3 (17q21-22), SMARCA4 (19p13.3) LIG1 (19q13.3), UBE2C (20q13.1), SMC1L1 (Xp11), KIF4A (Xq12), TMSNB (Xq22), and CSAG2 (Xq28).
|
17243165 |
2007 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations imply a deregulation of chromokinesin in retinoblastoma cells.
|
9168136 |
1997 |