STH, saitohin, 246744

N. diseases: 27; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021831
Disease: Intestinal Diseases
Intestinal Diseases 		0.010 AlteredExpression group BEFREE <b>Abbreviations</b>: CBA: Controlled Before and After; GSD: Government Service Delivery; IWDSSD: International Drinking-Water, Supply and Sanitation Decade (IDWSSD); KAP: Knowledge, Attitudes and Practices; IBD: Irritable Bowel Diseases; MDG: Millennium Development Goals; NTD: Neglected Tropical Diseases; PSSD: Private Sector Service Delivery; SDG: Sustainable Development Goals; SSA: Sub Saharan Africa; SODIS: Solar Disinfection System; STH: Soil Transmitted Helminths; RCT: Randomised Control Trial; WASH: Water Sanitation and Hygiene; WHO: World Health Organization. 30545246 2019
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.010 AlteredExpression disease BEFREE <b>Abbreviations</b>: CBA: Controlled Before and After; GSD: Government Service Delivery; IWDSSD: International Drinking-Water, Supply and Sanitation Decade (IDWSSD); KAP: Knowledge, Attitudes and Practices; IBD: Irritable Bowel Diseases; MDG: Millennium Development Goals; NTD: Neglected Tropical Diseases; PSSD: Private Sector Service Delivery; SDG: Sustainable Development Goals; SSA: Sub Saharan Africa; SODIS: Solar Disinfection System; STH: Soil Transmitted Helminths; RCT: Randomised Control Trial; WASH: Water Sanitation and Hygiene; WHO: World Health Organization. 30545246 2019
CUI: C0033375
Disease: Prolactinoma
Prolactinoma 		0.010 Biomarker disease BEFREE Our study provides the evidence that a higher Ki-67 value is associated with pituitary adenomas that secrete PRL (prolactinomas and mixed STH/PRL-secreting adenomas). 28432860 2017
CUI: C0036323
Disease: Schistosomiasis
Schistosomiasis 		0.010 Biomarker disease BEFREE Spatial modelling of STH and schistosomiasis epidemiology is now commonplace. 28005901 2016
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 GeneticVariation group BEFREE Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a concurring factor in hypofrontality, we hypothesize that STH and COMT polymorphisms could have an additive effect on cognition in schizophrenia. 25283873 2015
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 GeneticVariation phenotype BEFREE Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a concurring factor in hypofrontality, we hypothesize that STH and COMT polymorphisms could have an additive effect on cognition in schizophrenia. 25283873 2015
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.010 GeneticVariation disease BEFREE After the stratification analysis according to gender, both male and female PD patients showed association with the alleles and genotypes of the rs62063857 polymorphism of the saitohin gene (χ2 = 9.476, P = 0.009; χ2 = 7.593, P = 0.022, respectively). 25168738 2015
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.010 GeneticVariation phenotype BEFREE The present study sought to evaluate the possible role of the STH polymorphism as a concurring factor of cognitive decline in schizophrenia, a disease sharing both early psychotic manifestations, a core deficit of executive functions and hypofrontality with frontotemporal lobe dementia. 22187337 2012
CUI: C2748208
Disease: Executive dysfunction
Executive dysfunction 		0.010 GeneticVariation disease BEFREE Saitohin polymorphism and executive dysfunction in schizophrenia. 22187337 2012
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.010 Biomarker phenotype BEFREE We found a 439-kb microduplication at the 17q21.31 locus encompassing the MAPT, IMP5, CRHR1, and STH genes in the index case of a family in which three patients have developed a FTLD phenotype associated with marked memory impairment. 20634582 2010
CUI: C0542476
Disease: Forgetful
Forgetful 		0.010 Biomarker phenotype BEFREE We found a 439-kb microduplication at the 17q21.31 locus encompassing the MAPT, IMP5, CRHR1, and STH genes in the index case of a family in which three patients have developed a FTLD phenotype associated with marked memory impairment. 20634582 2010
CUI: C0751072
Disease: Frontotemporal Lobar Degeneration
Frontotemporal Lobar Degeneration 		0.010 GeneticVariation disease BEFREE We found a 439-kb microduplication at the 17q21.31 locus encompassing the MAPT, IMP5, CRHR1, and STH genes in the index case of a family in which three patients have developed a FTLD phenotype associated with marked memory impairment. 20634582 2010
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.010 GeneticVariation disease LHGDN This study genotyped 37 subjects with diagnosis of Huntington's disease, but lacking mutations in HD, PRNP, JPH-3, and FTL genes for STH polymorphism. 18300012 2008
CUI: C0338460
Disease: Argyrophilic grain disease
Argyrophilic grain disease 		0.010 GeneticVariation disease BEFREE Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. 15030402 2004
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia 		0.020 GeneticVariation disease BEFREE 220 clinically stabilized patients with schizophrenia were assessed with the Wisconsin Card Sorting Test (WCST) for evaluation of executive functions and compared for STH allele frequency with 48 patients affected by frontotemporal dementia and 47 healthy subjects. 22187337 2012
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.020 GeneticVariation disease BEFREE A polymorphism (Q7R) in saitohin gene inside the microtubule-associated protein tau gene has also been related to dementia. 20852909 2010
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.020 GeneticVariation disease BEFREE We also observed a trend in non-Hispanic white PDD cases with the STH 'QQ' (Tau H1/H1) genotype increased (76%) compared to PD cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P=0.2). 12865131 2003
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia 		0.020 Biomarker disease BEFREE Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia. 12826737 2003
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.020 GeneticVariation group BEFREE Given that AD is a tauopathy but no mutations or polymorphisms in Tau have been consistently associated with AD, and that Saitohin is nested in intron 9 of Tau and shares a similar expression pattern, we tested this association in 690 multiplex AD families and in a case-control sample (903 patients and 320 controls). 12875906 2003
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.020 GeneticVariation group BEFREE Thus, the saitohin Q allele, which is a novel determinant of the tau H1 haplotypes, might represent a causative factor involved in the determinism of several tauopathies. 12447938 2002
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.020 GeneticVariation group LHGDN Thus, the saitohin Q allele, which is a novel determinant of the tau H1 haplotypes, might represent a causative factor involved in the determinism of several tauopathies. 12447938 2002
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.030 Biomarker disease BEFREE Our results showed a significant interaction effect of COMT and STH polymorphisms on cognitive performances, strengthening the involvement of STH in cognitive impairments, especially in the domains commonly impaired in schizophrenia. 25283873 2015
CUI: C0236642
Disease: Pick Disease of the Brain
Pick Disease of the Brain 		0.030 GeneticVariation disease BEFREE 220 clinically stabilized patients with schizophrenia were assessed with the Wisconsin Card Sorting Test (WCST) for evaluation of executive functions and compared for STH allele frequency with 48 patients affected by frontotemporal dementia and 47 healthy subjects. 22187337 2012
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.030 GeneticVariation disease BEFREE The present study sought to evaluate the possible role of the STH polymorphism as a concurring factor of cognitive decline in schizophrenia, a disease sharing both early psychotic manifestations, a core deficit of executive functions and hypofrontality with frontotemporal lobe dementia. 22187337 2012
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.030 GeneticVariation disease BEFREE Single polymorphisms within the saitohin and APOE genes were associated with increased cognitive impairment and functional dependence. 21934306 2011