|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a concurring factor in hypofrontality, we hypothesize that STH and COMT polymorphisms could have an additive effect on cognition in schizophrenia.
|
25283873 |
2015 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
220 clinically stabilized patients with schizophrenia were assessed with the Wisconsin Card Sorting Test (WCST) for evaluation of executive functions and compared for STH allele frequency with 48 patients affected by frontotemporal dementia and 47 healthy subjects.
|
22187337 |
2012 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Among the patients with schizophrenia, stratified for age and gender, the STH polymorphism resulted in a significant predictor of WCST performance (p = 0.007).
|
22187337 |
2012 |
|
Parkinson Disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
In this study, the saitohin rs62063857 polymorphism was associated with Parkinson's disease (χ2 = 16.765; P = 0.000).
|
25168738 |
2015 |
|
Parkinson Disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Both of MAPT_238bp/STH Q7R polymorphisms had a significant association with PD risk in all genetic models.
|
25305495 |
2014 |
|
Parkinson Disease
|
0.160 |
GeneticVariation
|
disease |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
Parkinson Disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Herein, we examined the association of H1 and PD in three Caucasian PD patient-control series from Ireland, Norway, and the US (combined: n = 2619), by genotyping two H1/H2 single nucleotide polymorphisms (SNPs) in MAPT (rs1052553) and in the Saitohin gene (rs62063857) and one H1-specific SNP (rs242557).
|
19912324 |
2010 |
|
Parkinson Disease
|
0.160 |
Biomarker
|
disease |
BEFREE |
In addition, postmortem brain samples from patients with PD and neurologically normal controls were used to evaluate whether the expression of the 3-repeat and 4-repeat isoforms of MAPT, and neighboring genes Saitohin (STH) and KIAA1267, are altered in PD cerebellum.
|
18509094 |
2008 |
|
Parkinson Disease
|
0.160 |
Biomarker
|
disease |
BEFREE |
Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease.
|
14966169 |
2004 |
|
Parkinson Disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.
|
12865131 |
2003 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we performed this meta-analysis to explore the association between STH Q7R polymorphism and AD risk.
|
28211174 |
2017 |
|
Primary biliary cirrhosis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Saitohin and APOE polymorphisms influence cognition and function in persons with advanced Alzheimer Disease.
|
21934306 |
2011 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: preliminary findings.
|
20852909 |
2010 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease.
|
18396294 |
2008 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Q7R polymorphism is unlikely to contribute significantly to Alzheimer's disease susceptibility of the Han population in south China and the variation of the Q7R polymorphism among different ethnic groups might account for the varied clinical manifestations of some STH-related diseases.
|
18850062 |
2008 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We used real-time PCR to investigate the level of expression of tau mRNA isoforms and STH mRNA in the frontal cortex and globus pallidus of PSP patients' brains. mRNA levels were compared with those in the brains of two controls groups: healthy controls and Alzheimer's disease patients (AD).
|
17320831 |
2007 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that both the GSK-3beta (-50) and STH (Q7R) polymorphisms increase the risk of late-onset (subjects >72 years) AD, although they appear to be independent and thus not to interact synergistically.
|
16428884 |
2006 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the STH gene has been suggested to be involved in sporadic AD and is in complete linkage disequilibrium with the TAU haplotype H1.
|
16909000 |
2005 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease.
|
15030402 |
2004 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, we failed to replicate the reported association between the Saitohin gene located in the tau intron 9 and Japanese Alzheimer's disease.
|
15106853 |
2004 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The STH-G allele appears to be a risk modifier for AD.
|
15136700 |
2004 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.
|
12865131 |
2003 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The current study reveals that increased risk of AD associated with the STH RR genotype (OR 2.17, p = 0.04) is limited to late-onset (after the age of 72 years) AD cases.
|
12826738 |
2003 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current study reveals that increased risk of AD associated with the STH RR genotype (OR 2.17, p = 0.04) is limited to late-onset (after the age of 72 years) AD cases.
|
12826738 |
2003 |