IL27, interleukin 27, 246778

N. diseases: 286; N. variants: 14
Disease: Immune thrombocytopenic purpura ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0398650
Disease: Immune thrombocytopenic purpura
Immune thrombocytopenic purpura 		0.040 GeneticVariation disease BEFREE Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP. 26950245 2016
CUI: C0398650
Disease: Immune thrombocytopenic purpura
Immune thrombocytopenic purpura 		0.040 AlteredExpression disease BEFREE The percentage of Th1 and Th17 cells and the plasma concentration and mRNA levels of IL-27 were significantly higher in cITP patients compared with healthy controls. 24909905 2014
CUI: C0398650
Disease: Immune thrombocytopenic purpura
Immune thrombocytopenic purpura 		0.040 GeneticVariation disease BEFREE In conclusion, the IL-27 polymorphism may not be involved in susceptibility to ITP in a Chinese population. 23937109 2013
CUI: C0398650
Disease: Immune thrombocytopenic purpura
Immune thrombocytopenic purpura 		0.040 Biomarker disease BEFREE In conclusion, IL-27 might play an important role in the pathogenesis of ITP by inducing the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines. 22210084 2012