|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study aimed at evaluating and comparing the chemical profile obtained by HPLC-ESI-MS<sup>n</sup> analysis, the inhibitory activity of enzymes linked to obesity (α-amylase, α-glucosidase, and lipase) and the antioxidant properties (DPPH, ABTS, FRAP, and β-carotene bleaching tests) of ethanol extracts of bulbs (BE) and aerial parts (APE) from Allium commutatum Guss.
|
31722087 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Preoperative use of metformin in obese women with endometrioid endometrial cancer (EEC) reduces tumor proliferation and inhibits the mammalian target of rapamycin pathway, though is only effective in select cases.
|
31808620 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, we suggest that mTOR may be a useful target in obesity research, given that its inhibition may decrease the hyperphagic response following caloric restriction.
|
30688487 |
2019 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Newly identified classes of mTOR inhibitors are being developed to block autoimmune diseases and transplant rejections but also to treat obesity, diabetes, and different types of cancer.
|
30609721 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results point to a novel role for miR-199a-3p and its downstream effector mTOR in human brown adipocyte differentiation and maintenance of thermogenic characteristics, which can be manipulated as therapeutic targets against obesity and its related metabolic disorders.
|
29753771 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Fatty acid administration, and PPARα and PPARδ (PPARα/δ) agonists, mimicked obesity and inhibited mechanistic target of rapamycin (mTOR)-mediated glycolysis.
|
30420624 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review, we aim to highlight the cross-talk between the gut microbiota and the mTOR pathway and discuss how this emerging field of research gives a beautiful insight into how the mentioned cross-talk impacts the body's homeostasis thus leading to undesirable complications including obesity, diabetes, colon and pancreatic cancer, immune system malfunctioning and ageing.
|
29548696 |
2018 |
|
Obesity
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Despite greater muscle mammalian target of rapamycin phosphorylation (P ≤ 0.05), fasted-state mixed-muscle and mitochondrial protein synthesis were lower in subjects with obesity (P ≤ 0.05).
|
29896930 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Genetic- and diet-induced obesity and insulin resistance are associated with an increase in mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue.
|
27692982 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The reduction of ghrelin expression and activation of the mTOR pathway might have opposite effects on food intake, as SG improves obesity and T2DM.
|
28974889 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of mTOR associates with various pathological conditions, such as obesity, neurodegeneration, and brain tumors.
|
29259984 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Hypersecretion of IGF1 causes increased expression of lipogenic genes via activating the protein kinase B (PKB; also known as Akt)-mammalian target of rapamycin (mTOR) pathway in adipose tissues, which contributes to the development of obesity, diabetes, and hepatic steatosis as the KI mice age.
|
27307439 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
The increased methylation rate of Tsc1 promoter in food-induced rat hypothalamus and up-regulated expression of mTOR, downstream gene of Tsc1 may promote the obesity.
|
25807795 |
2015 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Mouse models of obesity also exhibit increased hepatic activity of mammalian target of rapamycin complex 1 (mTORC1) and ER stress, and we found that administration of the mTOR inhibitor rapamycin to ob/ob mice reduced ER stress and increased hepatic sortilin-1 levels.
|
22466652 |
2012 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This short review focuses on effects of IFNT and progesterone affecting transport of select nutrients into the uterine lumen to stimulate mTOR cell signaling required for conceptus development, as well as effects of IFNT on the immune system and adiposity in rats with respect to its potential therapeutic value in reducing obesity.
|
23050969 |
2012 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common molecular event in a variety of pathological settings, including genetic tumor syndromes, cancer, and obesity.
|
20670887 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity.
|
19296907 |
2009 |