MTOR, mechanistic target of rapamycin kinase, 2475

N. diseases: 960; N. variants: 48
Disease: Addictive Behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.020 Biomarker phenotype BEFREE Activation of mTOR complex 1 (mTORC1) causes addiction to glucose and glutamine in Tsc1<sup>-/-</sup>or Tsc2<sup>-/-</sup> mouse embryonic fibroblasts (MEFs). 30622053 2019
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.020 Biomarker phenotype BEFREE Thus, this work for the first time shows that genetic alterations in the PI3K/Akt pathway confer thyroid cancer cells addiction to this pathway and their sensitivity to inhibition by targeting Akt and mTOR. 19706758 2009