FRZB, frizzled related protein, 2487

N. diseases: 89; N. variants: 8
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.030 PosttranslationalModification disease BEFREE Independent studies showed epigenetic silencing of SFRP3 in melanoma and hepatocellular carcinoma. 27623992 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE We found that recombinant SFRP3 could inhibit Wnt5a signaling, and that it inhibited melanoma cell migration and invasion in a Wnt5a-dependent manner. 21494614 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE We identified a panel of novel melanoma-associated markers: frizzled-related protein, an antagonist of Wnt; tranducin-like enhancer of split 1, a transcription factor partner of TCF/LEF-1; CNTN1, an activator of Notch signalling; two Serpin peptidase inhibitors, Serpin B3/B4 and the TGF-β family member GDF15, the latter with association to MAPK-signalling. 21410771 2011