|
Abetalipoproteinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three ABL (Abelson) kinase inhibitors prevented cell proliferation of HUVEC-TIE2-L914F.
|
30626204 |
2019 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fifty-two percent were MDD positive by RT-PCR and 37% had more than 10 copies of NPM-ALK per 10<sup>4</sup> copies of ABL (10NCNs) by qPCR.
|
29030834 |
2018 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
ABL (ABL1) and ARG (ABL2) are highly homologous to each other in overall domain structure and amino-acid sequence, with the exception of their C termini.
|
28386107 |
2017 |
|
Abetalipoproteinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrated that ABL SH3 mutant T79Y markedly repressed the expression of BCR-ABL signaling pathways in IM-resistant cell lines KCL22 and K562/G01 as well as IM-sensitive cell line K562.
|
26321052 |
2015 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using reverse 4',6-diamidino-2-phenylindole banding on metaphase cells, FISH analysis with BCR/ABL dual-fusion and ETV6 break-apart probes showed that a third ABL signal was inserted into 12p, splitting the ETV6 signal into two adjacent signals.
|
19480935 |
2009 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Numbers of NPM-ALK transcripts were normalized to 10(4) copies ABL (NCNs).
|
17392503 |
2007 |
|
Abetalipoproteinemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vitro treatment of human CML cell lines with imatinib or siRNA directed against BCR-ABL significantly reduced BCR-ABL while increasing CCN3 expression.
|
16670264 |
2006 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
All three minor BCR/ABL+ patients showed involvement of both B- and NK-cells, which was infrequent (27%, P = 0.06 and 10%, P = 0.01) among major BCR/ABL+ cases.
|
16487173 |
2006 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that TD-FISH effectively discriminates between cells with overlapping BCR and ABL signals from cells with true BCR/ABL fusion and improves the ability to quantify minimal residual disease from >23% to >1% of 500 interphase nuclei.
|
14697634 |
2004 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) analysis using BCR/ABL probes revealed five or more ABL signals, indicating amplification in 51.5% of interphase nuclei.
|
15282669 |
2004 |
|
Abetalipoproteinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we have explored the incidence of both typical and atypical iFISH patterns of BCR/ABL gene rearrangements in a series of 168 consecutive BCR/ABL+ patients--135 CML, 31 precursor B-ALL and two acute myeloblastic leukemia (AML) cases--and established their underlying genetic alterations through further molecular and chromosome analyses.
|
12764379 |
2003 |
|
Abetalipoproteinemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BCR-ABL signals from patient RNA samples were quantified relative to known amounts of K562 RNA and normalised to levels of ABL.
|
11896544 |
2002 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We established two different criteria for BCR-ABL positivity: by criterion A cells were scored as positive when BCR and ABL signals were overlapping or touching and by criterion B cells were positive if they satisfied criterion A or if the signals were separated by up to one signal diameter.
|
9087564 |
1997 |
|
Abetalipoproteinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We constructed a long-range restriction map of the tuberous sclerosis (TSC1) region of human chromosome 9q34, extending from ABL (T39-2-2) to D9S114.
|
7590733 |
1995 |
|
Abetalipoproteinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) analyses using BCR and ABL probes showed that in 20% of metaphases BCR and ABL signals were present on one chromosome 6 at 6p23, whilst in 80% of metaphases BCR and ABL signals were identified on both copies of chromosome 6.
|
7596189 |
1995 |