|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The introduction of the tyrosine kinase inhibitors (TKI) into the treatment of patients with Ph or BCR-ABL1-positive acute lymphoblastic leukemia has revolutionized the treatment of this poor prognosis acute leukemia.
|
28581459 |
2017 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our results showed CFTR was highly expressed in Ph+ acute leukemia, which protected and maintained the continuous activation of BCR-ABL and the canonical Wnt/β-catenin signaling pathway by decreasing PP2A phosphatase activity.
|
28445932 |
2017 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCR-ABL (Ph)-like acute leukemia-Pathogenesis, diagnosis and therapeutic options.
|
27665024 |
2017 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, ETV6-ABL1 fusion occurs in both lymphoid and myeloid leukemias; the genomic profile and clinical behavior resemble BCR-ABL1-positive malignancies, including the unfavorable prognosis, particularly of acute leukemias.
|
27229714 |
2016 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate whether the BTG1 deletions occur in other BCR-ABL1-positive acute leukemias besides BCP-ALL, we analyzed 44 leukemia cases harboring the BCR-ABL1 transcript [32 BCP-ALL, six mixed-phenotype acute leukemia (MPAL), and six chronic myeloid leukemia in B-lineage blast crisis (CML-BC)] by array-based comparative genomic hybridization and reverse transcription-PCR.
|
24998463 |
2014 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a novel fusion gene involving RUNX1 and the antisense strand of SV2B in a BCR-ABL1-positive acute leukemia.
|
24123676 |
2013 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A thorough review of the literature and an analysis of all published data, including the three new cases, suggest poor prognosis of ETV6/ABL1-positive acute leukemias.
|
20589932 |
2010 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A diphtheria toxin interleukin-3 fusion protein synergizes with tyrosine kinase inhibitors in killing leukemic progenitors from BCR/ABL positive acute leukemia.
|
20137810 |
2010 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The WT1 expression level showed positive correlation with the hypodiploidy and BCR-ABL fusion gene in acute leukemia.
|
20863155 |
2010 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cooperative activities of Zfp423 and p210BCR/ABL were demonstrated as follows: (1) introduction of Zfp423 in p210BCR/ABL transgenic bone marrow (BM) cells increased colony-forming ability, (2) suppression of ZNF423 (human homologue of Zfp423) in ZNF423-expressing, p210BCR/ABL-positive hematopoietic cells retarded cell growth, (3) mice that received a transplant of BM cells transduced with Zfp423 and p210BCR/ABL developed acute leukemia, and (4) expression of ZNF423 was found in human BCR/ABL-positive cell lines and CML BC samples.
|
19234145 |
2009 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrated that overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induces acute leukemia in a transgenic model for CML.
|
18193087 |
2008 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Constitutively activated mutants of the non-receptor tyrosine kinases (TK) ABL1 (Abelson murine leukemia viral (v-abl) homolog (1) protein) and JAK2 (JAnus Kinase 2 or Just Another Kinase 2) play a central role in the pathogenesis of clinically and morphologically distinct chronic myeloproliferative disorders but are also found in some cases of de novo acute leukemia and lymphoma.
|
18528425 |
2008 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Imatinib, a selective ABL kinase inhibitor has improved therapeutic outcome in patients with Philadelphia positive chronic or acute leukemia.
|
17852464 |
2007 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical applications of BCR-ABL molecular testing in acute leukemia.
|
12707370 |
2003 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, our results indicate that despite the high incidence of typical iFISH patterns of BCR/ABL gene rearrangements, atypical patterns are also found in BCR/ABL+ acute leukemias; the precise definition of the alteration present in individual cases is dependent on metaphase studies and molecular definition of the breakpoint.
|
12764379 |
2003 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCR-ABL is critical to the pathogenesis of chronic myelogenous leukemia and a subset of acute leukemias.
|
12755554 |
2003 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated a BCR-ABL-specific qPCR method using the LightCycler technology in 95 patients with Philadelphia chromosome positive acute leukemia (n = 7) or CML in different stages (n = 88).
|
12631253 |
2003 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCR/ABL fusion gene detected on 9q34 by fluorescence in situ hybridization in an acute leukemia with two BCR/ABL positive clones, one Ph-negative and one Ph-positive.
|
11734316 |
2001 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice injected intravenously with BCR/ABL-BaF3 cells developed acute leukemia and died within 4 weeks with massive splenomegaly, elevated white blood cell counts, and anemia.
|
11222387 |
2001 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A procedure for in-cell amplification of the hybrid BCR-ABL mRNA by reverse transcription and polymerase chain reaction (RT-PCR) without extraction of the nucleic acids was performed directly in fixed and permeabilized cells of leukemia patients (22 patients with Ph'-positive chronic myeloid leukaemia-CML and 1 with Ph'-positive acute leukaemia-AL, as well as 7 Ph'-negative cases) and Ph'-positive human leukaemia cell lines (K562, LAMA-84, BV173).
|
10674911 |
2000 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
T and C alleles were discriminated by a melting temperature difference of the reporter probe of 3.2 K. We have investigated cDNAs derived from leukocytes from seven cell lines and a total of 229 individuals: normal donors, n = 15; BCR-ABL negative chronic myeloproliferative disorders, n=30; BCR-ABL negative acute leukemias, n= 11; b2a2BCR-ABL positive CML, n = 93; and b3a2BCR-ABL positive CML, n= 80.
|
11069038 |
2000 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transposition of duplicated chromosomal segment involving fused BCR-ABL gene or ABL oncogene alone in chronic myelocytic leukemia and Ph chromosome-positive acute leukemia with complex karyotypes.
|
10812164 |
2000 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML.
|
9365838 |
1997 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent amounts of acute leukemia-associated P190BCR/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis.
|
8562932 |
1996 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
What is the contribution of molecular studies to the diagnosis of BCR-ABL-positive disease in adult acute leukemia?
|
8109597 |
1994 |