FUS, FUS RNA binding protein, 2521

N. diseases: 301; N. variants: 39
Disease: Childhood Liposarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE RBPs affected by excitotoxicity included TAR DNA-binding protein 43 (TDP-43) and, most robustly, fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS). 31092554 2019
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Regulatory mechanisms, expression levels and proliferation effects of the FUS-DDIT3 fusion oncogene in liposarcoma. 26865464 2016
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Amyotrophic lateral sclerosis (ALS) is caused by mutations in a number of genes, including the gene encoding the RNA/DNA-binding protein translocated in liposarcoma or fused in sarcoma (TLS/FUS or FUS). 26251528 2015
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 AlteredExpression disease BEFREE MMP-2-mRNA and protein expression correlated significantly with FUS-CHOP positivity in 46 resected patient liposarcoma tissues. 24285420 2014
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-/RNA-binding protein that is involved in a variety of cellular functions including transcription, protein translation, RNA splicing, and transport. 25289647 2014
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 GeneticVariation disease BEFREE Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). 25444610 2014
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is concentrated within cytoplasmic stress granules under conditions of induced stress. 24090136 2013
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 AlteredExpression disease BEFREE Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation. 23836491 2013
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE A real time PCR based approach for the quantitative detection of FUS-CHOP fusion transcripts in human liposarcoma. 22543255 2012
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Myxoid round cell liposarcoma (MRCLS) is a common liposarcoma subtype characterized by a translocation that results in the fusion protein TLS:CHOP as well as by mixed adipocytic histopathology. 22293175 2012
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein (TARDBP, also known as TDP43) and fused in sarcoma (FUS, also known as translocated in liposarcoma (TLS)) account for approximately 30% of classic familial ALS. 21857683 2011
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 GeneticVariation disease BEFREE We thus investigated whether the loss of one FUS allele by translocation in liposarcoma may be followed by mutations in either the remaining FUS allele or the paralogous EWSR1. 21344536 2011
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 AlteredExpression disease BEFREE These results indicate that FUS-CHOP expression in a p53-deficient background is sufficient to initiate liposarcoma in mouse but not in hASCs, suggesting the need of additional cooperating mutations in hASCs. 21732477 2011
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Fused in sarcoma/translocated in liposarcoma: a multifunctional DNA/RNA binding protein. 20541619 2010
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE In light of these findings we also analyze the potential significance of a novel association between ALS, altered autophagy, and mutations of nuclear proteins such as TAR-DNA-Binding Protein 43 and fused in sarcoma/translated in liposarcoma. 20406184 2010
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Current studies indicate that FUS-DDIT3- liposarcoma develops from uncommitted progenitors. 18596980 2008
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Taken together, this study provides genetic evidence that the presence of FUS-DDIT3 in an aP2-positive cell is not enough to cause liposarcoma development and establishes that PPARgamma inactivation is required for liposarcoma development. 17468515 2007
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 GeneticVariation disease BEFREE We aimed to study the usefulness of trabectedin in the treatment of patients with myxoid liposarcomas, a subtype of liposarcoma that is associated with specific chromosomal translocations t(12;16)(q13;p11) or t(12;22)(q13;q12) that result in the formation of DDIT3-FUS or DDIT3-EWSR1 fusion proteins. 17586092 2007
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE In conclusion, because the fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype when expressed in a primitive sarcoma cell line, MLS/RCLS may develop from cell types other than preadipocytes. 16651630 2006
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 GeneticVariation disease BEFREE The cytogenetic hallmark of myxoid type and round cell type liposarcoma consists of reciprocal translocation of t(12;16)(q13;p11) and t(12;22)(q13;q12), which results in fusion of TLS/FUS and CHOP, and EWS and CHOP, respectively. 16884691 2006
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 GeneticVariation disease BEFREE The aim of this study was to detect the chromosomal translocation t(12;16)(q13;p11) that leads to a gene fusion encoding a FUS-CHOP chimeric protein and has been shown to be highly characteristic of myxoid and round cell subtypes of liposarcoma, in a case of oral myxoid liposarcoma. 16414544 2006
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 AlteredExpression disease BEFREE Molecular analysis demonstrated for the first time the presence of FUS-CHOP transcript in this liposarcoma variant. 15720420 2005
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Understanding mesenchymal cancer: the liposarcoma-associated FUS-DDIT3 fusion gene as a model. 15826835 2005
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Our results provide genetic evidence that FUS and CHOP domains function in trans for the mutual restoration of liposarcoma. 11896599 2002
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.100 Biomarker disease BEFREE Downstream of the gene for the liposarcoma-associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M-LPS/RC-LPS) oncogene, TLS/FUS-CHOP. 12366807 2002