Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the largest study to date investigating the ES subset with EWSR1/FUS-FEV fusions showing a predilection for extraskeletal sites and aggressive behavior.
|
31756779 |
2020 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Despite these similarities, Ewing-like sarcomas lack the pathognomonic molecular hallmark of Ewing sarcoma: A translocation between a gene of the RNA-binding TET family (EWSR1 or FUS) with a gene of the ETS-transcription family ( FLI1, ERG, ETV1, ETV4, or FEV).
|
30257034 |
2019 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results were compared to methylation data of 30 EwS with various EWSR1-ETS fusions and one EwS with FUS-ERG fusion, 16 URCS with CIC rearrangement and 10 URCS with BCOR alteration and a total of 81 EWSR1-associated soft tissue sarcomas including 7 angiomatoid fibrous histiocytomas, 7 clear cell sarcomas of the soft tissue, 28 desmoplastic small round cell tumors, 10 extraskeletal myxoid chondrosarcomas and 29 myxoid liposarcomas.
|
30895378 |
2019 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, mouse mesenchymal cells transformed with either the <i>EWS-FLI1</i> or <i>FUS-CHOP</i> rearrangement displayed similar sensitivities to olaparib, whereas the Ewing's sarcoma cell line SK-N-MC had increased olaparib sensitivity.
|
29313488 |
2018 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Eribulin regresses a doxorubicin-resistant Ewing's sarcoma with a FUS-ERG fusion and CDKN2A-deletion in a patient-derived orthotopic xenograft (PDOX) nude mouse model.
|
28681998 |
2018 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, tumor from a patient with a Ewing's sarcoma with cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) loss and FUS-ERG fusion was implanted in the right chest wall of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model.
|
27286459 |
2016 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
During this investigation we came across a number of ERG-rearranged ES lacking both EWSR1 and FUS abnormalities by FISH.
|
26690869 |
2016 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The inclusions were immunoreactive for FUS, p62, and TATA-binding protein-associated factor 15 (TAF15), but not for phosphorylated tau, transactive response DNA-binding protein of 43 kDa (TDP-43), neurofilament protein, or Ewing sarcoma (EWS).
|
26227957 |
2016 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The strong IHC expression of SATB2 associated with CD99 immunonegativity and the absence of EWSR1 and FUS gene rearrangements in small cell osteosarcoma argues against the existence of a morphologic/genetic continuum with Ewing sarcoma.
|
25723116 |
2015 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FUS is a member of the FET protein family that includes Ewing's sarcoma (EWS) and TATA-binding protein-associated factor 2N (TAF15).
|
24899704 |
2014 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No rearrangement of Ewing sarcoma region 1 (EWSR1) and fused in sarcoma (FUS) genes was observed by fluorescent in situ hybridization.
|
23079205 |
2013 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
While ALS-FUS showed only accumulation of FUS, inclusions in FTLD-FUS revealed co-accumulation of all members of the FET protein family, that include FUS, Ewing's sarcoma (EWS) and TATA-binding protein-associated factor 15 (TAF15) suggesting a more complex disturbance of transportin-mediated nuclear import of proteins in FTLD-FUS compared to ALS-FUS.
|
22842875 |
2012 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cell culture experiments replicated the findings of amyotrophic lateral sclerosis with FUS mutations by confirming the absence of TATA-binding protein-associated factor 15 and Ewing's sarcoma alterations upon expression of mutant fused in sarcoma.
|
21856723 |
2011 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.
|
17620387 |
2007 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma.
|
16303180 |
2006 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These represent the first four cases where FUS, rather than EWS, is rearranged with an ETS-family transcription factor in Ewing's tumors.
|
12907633 |
2003 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The FUS (TLS)-ERG chimeric protein associated with t(16;21)(p11;q22) acute myeloid leukemia is structurally similar to the Ewing's sarcoma chimeric transcription factor EWS-ERG.
|
10523652 |
1999 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma.
|
8187069 |
1994 |