Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
|
8909999 |
1996 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
LHGDN |
Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma.
|
11819805 |
2001 |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
The human alpha-1,3/4 fucosyltransferase III (FucT III) catalyses the synthesis of Lewis antigens including Le(b) antigen which is a ligand for Helicobacter pylori adhesion.
|
12730721 |
2003 |
Infection
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population.
|
12730721 |
2003 |
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The strong correlation between the promoter activity of the FUT III gene and the high expression of sialyl Le(a) observed in different colon carcinoma cell lines seem to confirm the important regulatory role of FUT3 in the synthesis of sialyl Le(a).
|
16199102 |
2005 |
Alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
LES-hair provides a research tool for studying the basic biology of plucked hair follicles and has potential clinical applications such as monitoring treatment of alopecia or using plucked hair follicles as a surrogate tissue to monitor pharmacodynamic effects of targeted cancer therapies.
|
15942212 |
2005 |
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
|
17383304 |
2007 |
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
|
17383304 |
2007 |
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
|
17383304 |
2007 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Together, our observations point to a tumor induced transcription of endothelial FUT1 and consequently an enhanced expression of CD174 which is involved in migration and early cell-cell contacts during tumor associated angiogenesis.
|
18205178 |
2008 |
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using a bone marrow derived endothelial cell line we observed an enhanced expression of CD173/CD174 and transcription of FUT1, the key enzyme for their synthesis, after treatment with tumor necrosis factor-alpha (TNF-alpha) or conditioned supernatants of the leukemia cell line KG1a.
|
18205178 |
2008 |
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using a bone marrow derived endothelial cell line we observed an enhanced expression of CD173/CD174 and transcription of FUT1, the key enzyme for their synthesis, after treatment with tumor necrosis factor-alpha (TNF-alpha) or conditioned supernatants of the leukemia cell line KG1a.
|
18205178 |
2008 |
Cystic Fibrosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the genes encoding ABO blood type, secretor or Lewis genotypes were not shown to associate with severity of CF lung disease, or age of onset of P. aeruginosa infection, nor was there any association with other clinical phenotypes in a group of 808 patients homozygous for the DeltaF508 mutation.
|
19169360 |
2009 |
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using quantitative RT-PCR, we demonstrated that FUT4 and FUT7 are the predominant FUTs expressed in hematopoietic cell line, while FUT3 is heavily expressed by multiple cancer cell lines including the prostate cancer cell line MDA PCa2b.
|
20833389 |
2010 |
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using quantitative RT-PCR, we demonstrated that FUT4 and FUT7 are the predominant FUTs expressed in hematopoietic cell line, while FUT3 is heavily expressed by multiple cancer cell lines including the prostate cancer cell line MDA PCa2b.
|
20833389 |
2010 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor-α (TNF-α) up-regulates FucT-III, resulting in increased sLeX in the airways of patients with respiratory disease; however, the mechanisms that regulate sLeX in the inflammatory tumor microenvironment are not well understood.
|
21437888 |
2011 |
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The current results indicated that neutrophils may be recruited to areas of FucT-III activity and sLeX expression in lung carcinomas to enhance the invasive and metastatic potential of lung cancer cells.
|
21437888 |
2011 |
Respiration Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Tumor necrosis factor-α (TNF-α) up-regulates FucT-III, resulting in increased sLeX in the airways of patients with respiratory disease; however, the mechanisms that regulate sLeX in the inflammatory tumor microenvironment are not well understood.
|
21437888 |
2011 |
Respiratory Tract Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Tumor necrosis factor-α (TNF-α) up-regulates FucT-III, resulting in increased sLeX in the airways of patients with respiratory disease; however, the mechanisms that regulate sLeX in the inflammatory tumor microenvironment are not well understood.
|
21437888 |
2011 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The current results indicated that neutrophils may be recruited to areas of FucT-III activity and sLeX expression in lung carcinomas to enhance the invasive and metastatic potential of lung cancer cells.
|
21437888 |
2011 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The authors stably transfected human lung carcinoma cell lines with the FucT-III gene and exposed them to TNF-α to investigate its role in regulation of sLeX expression and selectin-binding ability using semiquantitative real-time polymerase chain reaction and flow cytometry.
|
21437888 |
2011 |
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The current results indicated that neutrophils may be recruited to areas of FucT-III activity and sLeX expression in lung carcinomas to enhance the invasive and metastatic potential of lung cancer cells.
|
21437888 |
2011 |
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Serum LDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |