Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.050 GeneticVariation disease BEFREE The majority of patients who undergo a laparoscopic fundoplication for gastroesophageal reflux disease (GERD) have a structural (hiatal hernia, shortened lower esophageal sphincter [LES]) or functional (weak LES) defect of the gastroesophageal junction (GEJ). 31214803 2020
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.050 GeneticVariation disease BEFREE Numerous studies demonstrate that POEM produces comparable, if not superior, results compared to standard laparoscopic Heller myotomy (LHM), as determined by LES pressure, dysphagia frequency, Eckardt score, hospital length of stay, therapy durability, and incidence of GERD. 31451984 2020
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.050 Biomarker disease BEFREE The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia. 29915812 2018
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.050 Biomarker disease BEFREE Gastro-esophageal reflux disease (GERD) may occur post-achalasia intervention due to disruption of the LES and therefore requires diligent follow-up, especially in children treated with POEM. 29439587 2018
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.050 GeneticVariation disease BEFREE There was a prevalence of acid reflux at both sphincters (p<0.0001); liquid reflux was prevalent at the LES (p=0.003) and mixed reflux at the UES (p=0.0001). 29307652 2018