Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0750880
Disease: Monocyte count result
Monocyte count result
0.100 GeneticVariation phenotype GWASCAT Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos. 28158719 2017
CUI: C2697788
Disease: Interleukin 8 Measurement
Interleukin 8 Measurement
0.100 GeneticVariation phenotype GWASCAT Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors. 27989323 2017
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 AlteredExpression group BEFREE These humoral factors can generally be divided into those which, like RANKL, are tumour necrosis family (TNF) superfamily members and those which are not; the former include TNFα lymphotoxin exhibiting inducible expression and competing with herpes simplex virus glycoprotein D for herpesvirus entry mediator, a receptor expressed by T lymphocytes (LIGHT), a proliferation inducing ligand (APRIL) and B cell activating factor (BAFF); the latter include transforming growth factor beta (TGF-β), interleukin-6 (IL-6), IL-8, IL-11, nerve growth factor (NGF), insulin-like growth factor-I (IGF-I) and IGF-II. 26578261 2016
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Herpes simplex virus glycoprotein D relocates nectin-1 from intercellular contacts. 27723487 2016
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200633
Disease: Neutrophil count (procedure)
Neutrophil count (procedure)
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200637
Disease: Monocyte count procedure
Monocyte count procedure
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200641
Disease: Blood basophil count (lab test)
Blood basophil count (lab test)
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0750880
Disease: Monocyte count result
Monocyte count result
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0857490
Disease: Granulocyte count
Granulocyte count
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells. 25878105 2015
CUI: C0019340
Disease: Herpes NOS
Herpes NOS
0.100 Biomarker disease BEFREE During viral entry, gD interacts with one of 4 host co-receptors: HVEM (herpes virus entry mediator), nectin-1, nectin-2 and 3-O-sulfated heparan sulfate. 25414835 2014
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE The most recent trial was the Herpevac Trial for Women that used gD2 with monophosphoryl lipid A and alum as adjuvants in herpes simplex virus type 1 (HSV-1) and HSV-2 seronegative women. 25138572 2014
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1. 24314649 2014
CUI: C2698399
Disease: Myeloperoxidase Measurement
Myeloperoxidase Measurement
0.100 GeneticVariation phenotype GWASDB Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. 23620142 2013
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE LIGHT [the name of which is derived from 'homologous to lymphotoxins, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for herpes simplex virus entry mediator (HVEM), and expressed by T lymphocytes'], is a member of the tumour necrosis factor superfamily that is involved in various inflammatory diseases. 22519595 2012
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure
0.100 GeneticVariation phenotype GWASCAT Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. 22037903 2012
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure
0.100 GeneticVariation phenotype GWASDB Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. 22037903 2012
CUI: C0162701
Disease: Polysomnography
Polysomnography
0.100 GeneticVariation phenotype GWASDB Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. 23251661 2012
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement
0.100 GeneticVariation phenotype GWASDB A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. 22291609 2012
CUI: C0424621
Disease: Body Fat Distribution
Body Fat Distribution
0.100 GeneticVariation phenotype GWASCAT Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche. 22744181 2012
CUI: C1314691
Disease: Age at menarche
Age at menarche
0.100 GeneticVariation phenotype GWASCAT Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche. 22744181 2012
CUI: C0019340
Disease: Herpes NOS
Herpes NOS
0.100 Biomarker disease BEFREE Although the complex structure of gD with herpes virus entry mediator has been established, the binding mode of gD with the nectin-1 is elusive. 22146396 2011
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Successful retargeting of herpes simplex virus type 1 (HSV-1) has been achieved using vectors that carry a modified envelope glycoprotein D (gD) engineered to interact directly with novel receptors. 20924362 2011