|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
African selected malaria resistance through the DARC gene was enriched in all Arabian genomes, especially in the western part.
|
30649405 |
2019 |
|
Malaria
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Individuals with benign neutropenia due to the ACKR1-null allele have been found to have an increased susceptibility to human immunodeficiency virus infection and, on the other hand, a protective effect against malaria.
|
30592023 |
2019 |
|
Malaria
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
The ability of the malaria parasite Plasmodium vivax to invade erythrocytes is dependent on the expression of the Duffy blood group antigen on erythrocytes.
|
27190089 |
2016 |
|
Malaria
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to estimate the prevalence of Plasmodium vivax and polymorphisms in the Duffy antigen receptor for chemokines (DARC) gene in patients with suspected malaria from eastern (Harar) and southwestern (Jimma) Ethiopia.
|
23584375 |
2013 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
The Duffy blood group antigen is the portal of entry of the Plasmodiumvivax malaria parasite into human red blood cells and the receptor for a number of CXC and CC chemokines.
|
20655790 |
2010 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
A second early example of inherited innate resistance to malaria was the finding that nonexpression of the Duffy antigen/chemokine receptor (DARC) on erythrocytes confers resistance to P. vivax.
|
19442502 |
2009 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
BEFREE |
The mutation may have implications for some physiological roles of DARC and be of interest in malaria research and in studies of population genetics.
|
9746760 |
1998 |
|
Malaria
|
0.370 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Arteriovenous fistula
|
0.200 |
Biomarker
|
phenotype |
RGD |
Duffy antigen / receptor for chemokines correlates with inflammatory reaction in rats with venous hypertension: implication for the pathogenesis of primary chronic venous disease.
|
24429330 |
2014 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the defined region on gD of BoHV-1 might be essential in viral entry upon comparison with the prototype virus in herpes simplex virus (Alphaherpesvirinae).
|
31654778 |
2020 |
|
Herpes Simplex Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In adult mice, a single-cycle HSV candidate vaccine deleted in glycoprotein-D (ΔgD-2) that induces ADCC provided complete protection against HSV disease and prevented the establishment of latency.
|
31599942 |
2020 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) plays a key role in multiple events during infection including virus entry, cell-to-cell spread, and virus-induced syncytia formation.
|
30465930 |
2019 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Female C57BL/6J mice were immunized rectally (IR) or intramuscularly (IM) with rVCG co-expressing the <i>Chlamydia trachomatis</i> PmpD and PorB proteins (rVCG- PmpD/PorB) with and without FL or glycoprotein D of HSV-2 (rVCG-gD2) as antigen control.
|
31333682 |
2019 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our approach towards vaccine development is to focus on blocking virus entry mediated by herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) and to prevent the virus from evading complement and antibody attack by blocking the immune evasion domains on HSV-2 glycoproteins C (gC2) and E (gE2), respectively.
|
30551986 |
2019 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig model of genital herpes.
|
30917165 |
2019 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, we evaluated a new adjuvant approach for anticancer immunotherapy using a plasmid vector encoding a soluble form of the IL-10 receptor (pIL-10R). pIL-10R was coadministered to mice with a DNA vaccine encoding the type 16 human papillomavirus (HPV-16) E7 oncoprotein genetically fused with glycoprotein D of herpes simplex virus (HSV) (pgDE7h).
|
30806747 |
2019 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
We evaluated a trivalent glycoprotein vaccine containing herpes simplex virus type 2 (HSV-2) entry molecule glycoprotein D (gD2) and two immune evasion molecules: glycoprotein C (gC2), which binds complement C3b, and glycoprotein E (gE2), which blocks immunoglobulin G (IgG) Fc activities.
|
31541030 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
|
31675503 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neutrophil count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia.
|
30647433 |
2019 |
|
Neutrophil count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
|
31675503 |
2019 |
|
Monocyte count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
|
31675503 |
2019 |
|
Monocyte count result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
|
31675503 |
2019 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Five healthy adult dogs received a mixture of three replication-defective chimpanzee-derived adenoviral vectors, one expressing mouse fibroblast-associated protein (mFAP) and the others expressing canine melanoma-associated antigens Trp-1 or Trp-2 fused into Herpes Simplex-1 glycoprotein D, a checkpoint inhibitor of herpes virus entry mediator (HVEM) pathways.
|
30051333 |
2018 |