|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Five healthy adult dogs received a mixture of three replication-defective chimpanzee-derived adenoviral vectors, one expressing mouse fibroblast-associated protein (mFAP) and the others expressing canine melanoma-associated antigens Trp-1 or Trp-2 fused into Herpes Simplex-1 glycoprotein D, a checkpoint inhibitor of herpes virus entry mediator (HVEM) pathways.
|
30051333 |
2018 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Decoy receptor 3 (DcR3) competitively binds to Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) and TNF-like ligand 1A (TL1A), thereby preventing their effects.
|
28696795 |
2018 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed spontaneous osteoclastogenesis with a significant increase in OC formation and bone resorbing activity in late-stage CKD and HD patients when compared with early-stage CKD patients and healthy donors, likely due to an increased expression of RANKL and LIGHT (homologous to Lymphotoxins exhibiting Inducible expression and competing with herpes simplex virus Glycoprotein D for herpes virus entry mediator [HVEM], a receptor expressed by T lymphocytes) in PBMCs.
|
28992140 |
2018 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders.
|
29952668 |
2018 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to 3-<i>O</i>-sulfated HS, HSV-1 gD was reported to interact with other receptors, including herpes virus entry mediator (HVEM), nectin-1 and -2.
|
28174681 |
2017 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
During viral entry, gD interacts with one of 4 host co-receptors: HVEM (herpes virus entry mediator), nectin-1, nectin-2 and 3-O-sulfated heparan sulfate.
|
25414835 |
2014 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the complex structure of gD with herpes virus entry mediator has been established, the binding mode of gD with the nectin-1 is elusive.
|
22146396 |
2011 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF14), which serves as a receptor for herpes viruses and cytokines such as lymphotoxin-alpha (LT-alpha) and LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for herpes virus entry on T cells).
|
19680232 |
2010 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
The secreted form of gD, gDdTM, was used to detect antibody to herpes B virus gD.
|
17989200 |
2008 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
A strategy for systemic delivery of the oncolytic herpes virus HSV1716: redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein.
|
18701918 |
2008 |
|
Herpes NOS
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of herpes simplex virus glycoprotein D receptors nectin-1 and herpes virus entry mediator was assessed by quantitative fluorescence-activated cell sorter and correlated with NV1023 entry and oncolysis.
|
17327376 |
2007 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
The molecular mechanisms of apoptosis caused by IFN-gamma (interferon gamma)/LIGHT (lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells) have not been studied in detail.
|
17390046 |
2007 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, we discuss the findings about LIGHT (homologous to lymphotoxins, inducible expression, competes with herpes simplex virus glycoprotein D for herpes viral entry mediator, a receptor expressed on T lymphocytes) in the pathogenesis of IBD, and the potential mechanisms by which LIGHT induces IBD.
|
15790356 |
2005 |
|
Herpes NOS
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, increased expression of LIGHT (homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycoprotein D for herpes virus entry mediator on T cells) on T cells, a member of the TNF family (TNFSF14) and a ligand for LTbetaR, could dramatically increase the number of T cells and DCs, which leads to severe autoimmune diseases in a LTbetaR-dependent fashion.
|
16272360 |
2005 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
DcR3/TR6, a secreted protein belonging to the TNF receptor superfamily, interacts with lymphotoxin-like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entrance mediator (LIGHT), Fas ligand (FasL), and TL1A, all members of the TNF superfamily.
|
15814697 |
2005 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of LIGHT (LIGHT: homologous to lymphotoxins, indicating inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator [HVEM/TR2]) in MDA-MB-231 human breast cancer cells was observed to suppress tumor growth in vivo.
|
12651068 |
2003 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a herpes B virus-specific glycoprotein d immunodominant epitope recognized by natural and foreign hosts.
|
12195371 |
2002 |
|
Herpes NOS
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice.
|
2986288 |
1985 |