CERS6, ceramide synthase 6, 253782

N. diseases: 58; N. variants: 7
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.030 Biomarker disease BEFREE Thus, CerS6 appear to play an important role in the development of obesity and insulin resistance. 30655217 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.030 Biomarker disease BEFREE Here we demonstrate that the C<sub>16:0</sub> sphingolipid synthesizing ceramide synthases, CerS5 and CerS6, affect distinct sphingolipid pools and that abrogation of CerS6 but not of CerS5 protects from obesity and insulin resistance. 31150623 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.030 Biomarker disease BEFREE These experiments highlight CerS6 inhibition as a specific approach for the treatment of obesity and type 2 diabetes mellitus, circumventing the side effects of global ceramide synthesis inhibition. 25295788 2014