Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
(d) Examination of family-based samples has identified several genes including GABRA2 and CHRM2 thought to be associated with alcohol dependence.
|
16612210 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A consistent elevation in risk for alcohol dependence associated with GABRA2 is not evident until the mid-20s and then remains throughout adulthood.
|
16557364 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
A few candidate genes such as GABRA2 have shown robust associations with alcoholism.
|
24091936 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A SNP variant of rs279871, in the chromosome 4 gene encoding gamma-aminobutyric acid receptor (GABRA2), was selected due to its associations with alcoholism in young adults and with behaviors that increased risk for early drinking.
|
28847377 |
2017 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although our study was limited by the number of cases being larger than the number of controls, the results confirm GABRA2 as a susceptibility gene for alcohol dependence in the German population.
|
16395124 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although the analysis provided nominal support for an association with rs9291283 and AAD in adulthood and CD in adolescence, the current study failed to replicate previous associations between two well replicated GABRA2 SNPs and CD and alcohol dependence.
|
24687270 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Although the analysis provided nominal support for an association with rs9291283 and AAD in adulthood and CD in adolescence, the current study failed to replicate previous associations between two well replicated GABRA2 SNPs and CD and alcohol dependence.
|
24687270 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among these genes, GABRA1 is a member of the same gene family with GABRA2 that was recently reported as alcoholism susceptibility gene.
|
16451705 |
2005 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample.
|
16622805 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Based on a haplotypic association of alcohol dependence with the gene encoding the GABA(A) receptor alpha-2 subunit (GABRA2), we examined whether GABRA2 alleles are associated with the subjective response to alcohol.
|
15702134 |
2005 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Based on a haplotypic association of alcohol dependence with GABRA2, we investigated whether GABRA2 alleles are associated with the subjective responses to clamped alcohol concentration.
|
21118274 |
2011 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF.
|
22047728 |
2011 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Consistent with previous findings, the results do not support the association between GABRA2 SNP rs279871 and AD in adolescents.
|
19783384 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
First, we tested whether a single nucleotide polymorphism within GABRA2 gene, which encodes a subunit of the GABA(A) receptor, and that has been associated with AD, influences 'extreme' alcohol intake and second, the efficacy of three psychotherapies for alcoholism in treating extreme drinking behavior.
|
20225194 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
|
22253714 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.
|
18818659 |
2009 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping for seven GABRA2 single nucleotide polymorphisms (SNPs), identified from the literature as positively associated with alcohol dependence, was performed with success rates of 90% or greater.
|
21683760 |
2011 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of the 3 single nucleotide polymorphisms (SNPs) across the GABRA2 gene (rs567926, rs279858 and rs9291283) was performed in patients with alcohol dependence (N=654) and healthy control subjects (N=574).
|
26116794 |
2015 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.
|
21483437 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition, a gene encoding one of the receptors for the neurotransmitter γ-aminobutyric acid (GABA) known as GABRA2 seems to have a role in the development of alcohol dependence.
|
23134043 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In summary, these results extend previous findings and provide new insights into the putative biobehavioral mechanisms that may moderate the association between the GABRA2 gene, sensitivity to the acute effects of alcohol and ultimately alcohol dependence.
|
18005236 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this paper we summarize published results from linkage and association analyses of two chromosomal regions in which the use of endophenotypes has successfully led to the identification of genes associated with alcohol dependence [GABRA2 (Edenberg et al., (2004).Am.J. Hum.Genet.
|
16341909 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004).
|
20698837 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25.
|
23692184 |
2014 |