Disease: Alcohol Use Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.030 Biomarker disease BEFREE Future studies are needed to elucidate the exact role of PCSK9 in ALD and alcohol use disorder (AUD) and to evaluate efficacy and safety of anti-PCSK9 treatment in clinical populations with ALD/AUD. 31748600 2019
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.030 AlteredExpression disease BEFREE Plasma PCSK9 levels were correlated positively with CSF PCSK9 levels in AUD (p = 0.0493). 30933362 2019
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.030 Biomarker disease BEFREE Replication in AUD datasets confirmed PCSK9 hypomethylation and a translational mouse model of AUD showed that alcohol exposure leads to PCSK9 downregulation. 28848234 2018