Further gain-of-function study showed that ZBTB28 functions as a tumor suppressor inhibiting carcinoma cell growth <i>in vitro</i> and <i>in vivo</i>, through inducing cell cycle arrest and apoptosis of tumor cells.
Although it was recently demonstrated that reduced expression of BCL6B is associated with tumor stage and lymph node metastasis in CRC, little is known on whether BCL6B contributes to CRC development, or the related underlying mechanism.
BCL6B is a potential tumor suppressor in human gastric cancer, but the regulation and mechanism of BCL6B in human hepatocellular carcinogenesis remain unclear.
We previously showed that BCL6B acts as a tumor suppressor in gastric cancer and up to 66% gastric cancer patients have promoter hypermethylation in tumor tissues.