GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 AlteredExpression disease BEFREE Emotional processing theory variables did not predict any anxiety outcomes at posttreatment or follow-up with one exception: Initial fear activation predicted less anxiety at follow-up among youth without GAD. 27355694 2019
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE In this pilot study, nineteen female students participating on a NCAA Division III athletic team (hockey="in-season"; soccer="off-season") were compared for level of fitness (modified Balke test of VO<sub>2</sub> max), salivary IgA levels by immunoassay, anxiety (using a GAD-7 survey), salivary cortisol levels by immunoassay, and numbers of culturable bacteria by growth of CFU/ml on blood agar, mitis salivarius agar and Staphylococcus 110 agar. 27932242 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE The Generalized Anxiety Disorder Scales GAD-7 and GAD-2 are instruments for the assessment of anxiety. 28088111 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE The response rate, as measured by a 50% decrease in scores, for those with initial scores ≥10 was 58.6% for depression (PHQ-9) and 50% for anxiety (GAD-7). 28165775 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE A binary logistic regression analyses were conducted to test the association between all four ratings in GAD-7 (anxiety) and PHQ-9 (depression) scales subitems as covariates, and migraine vs no headache as the outcome. 28324317 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE The overall findings suggest that the workbook format was no less effective or acceptable than the validated online format.Significant improvements (avg. improvement; Internet Group vs Workbook Group) in levels of disability (PDI: 16% vs 24%; RMDQ: 12% vs 15%), anxiety (GAD-7: 36% vs 26%), and depression (PHQ-9: 36% vs 36%) were observed in both groups immediately posttreatment. 28394850 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE This hypothesis is supported by a higher rate of suicide among male Test cricketers when compared with the UK male general population.<sup>1</sup> METHODS: This study ascertained rates of anxiety and depression by screening professional cricket players using the Generalised Anxiety Disorder Questionnaire (GAD-7) and Patient Health Questionnaire (PHQ-9). 28490460 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE 18.3% of primary caregivers had symptoms of depression (based on PHQ-9 cut-off point of 10 or greater) while 12.7% had symptoms of anxiety (based on GAD-7 cut-off point of 10 or greater). 28526049 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Furthermore, self-rating questionnaires were used to assess somatic symptom severity (PHQ-15), depression severity (PHQ-9) and anxiety severity (GAD-7). 28554368 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Symptoms of depression and anxiety were measured using the Patient Health Questionnaire (PHQ-9) and the General Anxiety Disorder-7 (GAD-7). 29025788 2017
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Primary outcome measures will assess anxiety and depressive symptoms using the GAD-7 and PHQ-9, respectively. 29499675 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE 42.5% of the patients were rated as anxiety cases (sum scores GAD-7 > 5), mean scores of anxiety showed mild to moderate symptom severity, and 43% suffered from chronic pain before surgery. 29587759 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Patients also completed an anxiety screener (GAD-7). 29644783 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Secondary outcomes included clinician documentation of a goals-of-care conversation in the medical record and patient-reported quality of communication (Quality of Communication questionnaire [QOC]; 4-indicator latent construct) at 2 weeks, as well as patient assessments of goal-concordant care at 3 months and patient-reported symptoms of depression (8-item Patient Health Questionnaire; PHQ-8) and anxiety (7-item Generalized Anxiety Disorder survey; GAD-7) at 3 and 6 months. 29802770 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE Test Performance Characteristics of the AIR, GAD-7 and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease. 29986152 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE A previous study showed that knockdown of Gad1 from NPY+ cells led to reduced anxiety behaviors in adult mice. 30024942 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE There was no correlation between severity of depressive symptoms (as assessed by GDS-30 and BDI) with anxiety and depressive symptoms except for significant correlation between BDI total score and GAD-7 total score (Pearson correlation coefficient-0.319;p = 0.003).Factor analysis of GDS-30 yielded a five factor solution and when the items of other 3 scales were added, the number of factors/symptoms clusters increased to 7. 30054249 2019
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Among 2100 participants (1051 males and 1049 females), 475 (22.6%) were identified with anxiety (scoring 8 points or higher on the GAD-7 scale). 30125814 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE PWE from rural West China were evaluated for depression and anxiety with the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E; Chinese version) and the Generalized Anxiety Disorder-7 (GAD-7; Chinese version). 30125939 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Of the 36 women who started iCBT, 26 completed all three lessons of treatment (76% adherence rate). iCBT produced moderate to large effect size reductions for anxiety on the GAD-7 (Hedges' g = 0.76) and psychological distress on the Kessler-10 (g = 0.88) that were superior to TAU. 30266030 2019
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Of the 208 patients included in the study, 29 patients (13.9%) were positive for moderate-to-severe depression (PHQ-9 ≥ 10) and 22 patients (10.6%) were positive for anxiety (GAD-7 ≥ 10) symptoms. 30293440 2019
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE After completing the 4-week treatment program, patients showed significant improvements in depressed mood (t=3.642, p=0.001) based on the Patient Health Questionnaire-9 (PHQ-9), anxiety (t=3.198, p=0.003) based on the Generalized Anxiety Disorder seven-item (GAD-7) scale, and PTSD symptoms (t=5.363, p<0.001) based on the Posttraumatic Stress Disorder Check List (PCL). 30380815 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE In this single-centre approach, n = 1,000 adolescents will be screened (using PHQ-9 and GAD-7), and adolescents with results indicative of anxiety or depressive symptoms (n = 162) will be advised to seek psychological health care in clusters from treating physicians in specialised outpatient departments. 30428891 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 GeneticVariation disease BEFREE Measures included PHQ-9 (depression), GAD-7 (anxiety) and PCL-C (post-traumatic stress disorder). 30591033 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.100 Biomarker disease BEFREE Presence and frequency of depressive symptoms and anxiety were assessed by Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD-7). 30599337 2019