|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicate that NEGR1 deficiency induces abnormal fat deposition in various peripheral cells, especially fat and liver tissue cells, and suggest that NEGR1 is a potential molecular target for designing anti-obesity drugs to regulate body weight both centrally and peripherally.
|
31086253 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, genetic variants in or near the NEGR1 locus have been associated with obesity and more recently with learning difficulties, intellectual disability and psychiatric disorders.
|
29479305 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neuronal growth regulator 1 (NEGR1) is a newly identified raft-associated protein, which has recently been spotlighted as a new locus related to human obesity.
|
27940359 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We observed novel selection signals in CDKAL1 and NEGR1, well-known diabetes and obesity susceptibility genes.
|
25370040 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetics variants in the NEGR1 gene, strongly expressed in the brain, have been reported to affect the neuronal control of food intake therefore inducing obesity.
|
25245582 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the meta-analysis of 42 studies for 11 obesity/BMI-associated loci, we observed a statistically significant association of the FTO rs9939609 polymorphism (66 425 T2D cases/239 689 normoglycaemic subjects; P = 1·00 × 10(-41) ) and six other variants with T2D risk (17 915 T2D cases/27 531 normoglycaemic individuals: n = 40 629-130 001; all P < 0·001 for SH2B1 rs7498665, FAIM2 rs7138803, TMEM18 rs7561317, GNPDA2 rs10938397, BDNF rs925946 and NEGR1 rs2568958).
|
24528214 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity.
|
25072390 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 Population Architecture using Genomics and Epidemiology (PAGE) studies: the Multiethnic Cohort Study (1993-2006) (n = 19,529), the Atherosclerosis Risk in Communities Study (1987-1989) (n = 11,114), and the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, which accesses data from the Third National Health and Nutrition Examination Survey (1991-1994) (n = 6,347).
|
23820787 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15.
|
23843577 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05).
|
22083549 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1.
|
21796137 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|
19079261 |
2009 |