|
Cystic Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
LIV-I, a high-affinity system that transports neutral, branched-chain amino acids into Escherichia coli, has two components, LivG and LivF, that are homologous to the cystic fibrosis (CF) transmembrane conductance regulator (CFTR).
|
1718037 |
1991 |
|
Cholera
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of LIV-1 and pS2, two estrogen-responsive genes, are increased by the agents, cholera toxin (CT) plus 3-isobutyl-l-methylxanthine (IBMX), which cause an increase in cAMP in MCF-7 human breast cancer cells.
|
9027326 |
1996 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
LHGDN |
Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies.
|
11911440 |
2001 |
|
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Eleven of these genes had previously been associated with estrogen regulation or breast tumorigenesis including trefoil factor 1 and estrogen regulated LIV-1.
|
11911440 |
2001 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
CTD_human |
Combining the crucial role that zinc plays in cell growth and the proven role of metalloproteases in metastasis presents an exciting indication of how LIV-1 plays a role in breast cancer progression.
|
12839489 |
2003 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Combining the crucial role that zinc plays in cell growth and the proven role of metalloproteases in metastasis presents an exciting indication of how LIV-1 plays a role in breast cancer progression.
|
12839489 |
2003 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
CTD_human |
Combining the crucial role that zinc plays in cell growth and the proven role of metalloproteases in metastasis presents an exciting indication of how LIV-1 plays a role in breast cancer progression.
|
12839489 |
2003 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
CTD_human |
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
|
12839489 |
2003 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
|
12839489 |
2003 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
|
12839489 |
2003 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggest that LIV-1 is a promising candidate for a novel marker for breast cancer patients with better outcome.
|
15986450 |
2005 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggest that LIV-1 is a promising candidate for a novel marker for breast cancer patients with better outcome.
|
15986450 |
2005 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
LHGDN |
Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients.
|
15986450 |
2005 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
A negative correlation of LIV-1 protein levels with tumor size, grade and stage reflects an association of LIV-1 protein expression with less aggressive tumors.
|
15986450 |
2005 |
|
Invasive Ductal Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High LIV-1 protein expression seems to be associated with a longer relapse free and overall survival in breast cancer patients with invasive ductal carcinoma.
|
15986450 |
2005 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
LHGDN |
Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts.
|
17786585 |
2008 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway.
|
17825787 |
2007 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues.
|
17825787 |
2007 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues.
|
17825787 |
2007 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues.
|
17825787 |
2007 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In present study, the correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7 and the effect of LIV-1 expression on the cell growth were assessed to explore the possible mechanisms associated with this observation in breast cancer.
|
18330719 |
2009 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In present study, the correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7 and the effect of LIV-1 expression on the cell growth were assessed to explore the possible mechanisms associated with this observation in breast cancer.
|
18330719 |
2009 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
Biomarker
|
disease |
BEFREE |
Crucially, these observations link LIV-1, previously demonstrated to be associated with lymph node metastasis in breast cancer, to genes with a proven role in development.
|
18330719 |
2009 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis revealed that LIV-1 expression was frequently found in 76.4% of pancreatic carcinoma tissues and its expression level was associated with tumor size and lymphatic infiltration.
|
19724917 |
2009 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that anti-estrogen treatment regulates Zn level and importantly verify that Zip6 over-expression is not an underlying mechanism initiating breast cancer, but in fact may play a "tumor-constraining" role.
|
19852955 |
2010 |