|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that anti-estrogen treatment regulates Zn level and importantly verify that Zip6 over-expression is not an underlying mechanism initiating breast cancer, but in fact may play a "tumor-constraining" role.
|
19852955 |
2010 |
|
Mammary Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
Herein, we investigated the physiological relevance of Zip6 over-expression and the consequences of Zip6-attenuation in breast tumor cells as a mechanism in the development of anti-estrogen resistance.
|
19852955 |
2010 |
|
ESTROGEN RESISTANCE
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, we investigated the physiological relevance of Zip6 over-expression and the consequences of Zip6-attenuation in breast tumor cells as a mechanism in the development of anti-estrogen resistance.
|
19852955 |
2010 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Previous studies in our laboratory have shown that Zip-1, ZnT-1, Zip-2 and LIV-1 mRNA are associated with zinc level in established human breast cancer in nude mice model.
|
20859692 |
2011 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Previous studies in our laboratory have shown that Zip-1, ZnT-1, Zip-2 and LIV-1 mRNA are associated with zinc level in established human breast cancer in nude mice model.
|
20859692 |
2011 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then estimate a gene association network from gene expression data taken from a breast cancer tumor study, showing that scale-free structure prior recovers hubs, including the previously unknown hub SLC39A6, which is a zinc transporter that has been implicated with the spread of breast cancer to the lymph nodes.
|
21079769 |
2010 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then estimate a gene association network from gene expression data taken from a breast cancer tumor study, showing that scale-free structure prior recovers hubs, including the previously unknown hub SLC39A6, which is a zinc transporter that has been implicated with the spread of breast cancer to the lymph nodes.
|
21079769 |
2010 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
Despite the implication of LIV-1 in cancer growth and metastasis, there has been no study to determine the role of LIV-1 in prostate cancer progression.
|
22110740 |
2011 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Moreover, there was no clear delineation of the molecular mechanism underlying LIV-1 function in cancer cells.
|
22110740 |
2011 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Moreover, there was no clear delineation of the molecular mechanism underlying LIV-1 function in cancer cells.
|
22110740 |
2011 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
We characterized the mechanism by which LIV-1 drives human prostate cancer EMT in an androgen-refractory prostate cancer cells (ARCaP) prostate cancer bone metastasis model.
|
22110740 |
2011 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LIV-1 overexpressed ARCaP(E) cells had elevated levels of HB-EGF and matrix metalloproteinase (MMP) 2 and MMP 9 proteolytic enzyme activities, without affecting intracellular zinc concentration.
|
22110740 |
2011 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LIV-1 overexpressed ARCaP(E) cells had elevated levels of HB-EGF and matrix metalloproteinase (MMP) 2 and MMP 9 proteolytic enzyme activities, without affecting intracellular zinc concentration.
|
22110740 |
2011 |
|
Secondary malignant neoplasm of soft tissues
|
0.010 |
Biomarker
|
group |
BEFREE |
LIV-1 could be an attractive therapeutic target for the eradication of pre-existing human prostate cancer and bone and soft tissue metastases.
|
22110740 |
2011 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Herein, the physiological effects of zinc are reviewed in light of this mineral's role in cancer growth with specific attention being given to LIV-1 and the potential importance of this transporter to breast cancer etiology.
|
22852056 |
2012 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Herein, the physiological effects of zinc are reviewed in light of this mineral's role in cancer growth with specific attention being given to LIV-1 and the potential importance of this transporter to breast cancer etiology.
|
22852056 |
2012 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
LIV-1 (ZIP6) was first described in 1988 as an estrogen regulated gene with later work suggesting a role for this transporter in cancer growth and metastasis.
|
22852056 |
2012 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Herein, the physiological effects of zinc are reviewed in light of this mineral's role in cancer growth with specific attention being given to LIV-1 and the potential importance of this transporter to breast cancer etiology.
|
22852056 |
2012 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Herein, the physiological effects of zinc are reviewed in light of this mineral's role in cancer growth with specific attention being given to LIV-1 and the potential importance of this transporter to breast cancer etiology.
|
22852056 |
2012 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
Despite LIV-1 participates in cancer growth and metastasis, little is known about the association of LIV-1 with human liver cancer development.
|
23437163 |
2013 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Despite LIV-1 participates in cancer growth and metastasis, little is known about the association of LIV-1 with human liver cancer development.
|
23437163 |
2013 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Despite LIV-1 participates in cancer growth and metastasis, little is known about the association of LIV-1 with human liver cancer development.
|
23437163 |
2013 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Western blot showed the expression of LIV-1 was higher in 61% liver carcinoma tissues than that in normal liver tissues.
|
23437163 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.340 |
Therapeutic
|
disease |
CTD_human |
These results suggest that SLC39A6 has an important role in the prognosis of ESCC and may be a potential therapeutic target.
|
23644492 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.340 |
Biomarker
|
disease |
BEFREE |
These results suggest that SLC39A6 has an important role in the prognosis of ESCC and may be a potential therapeutic target.
|
23644492 |
2013 |