DisGeNET - a database of gene-disease associations

SIN3A, SIN3 transcription regulator family member A, 25942

N. diseases: 184; N. variants: 10

Disease: Leukemia, Myelocytic, Acute ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0023467
Disease:	Leukemia, Myelocytic, Acute

Leukemia, Myelocytic, Acute

0.020

AlteredExpression

disease

BEFREE

Notably, SIN3A expression shows prognostic value in AML.

29764005

2018

CUI:	C0023467
Disease:	Leukemia, Myelocytic, Acute

Leukemia, Myelocytic, Acute

0.020

Biomarker

disease

BEFREE

The downregulation of miR-22 in AML is caused by TET1/GFI1/EZH2/SIN3A-mediated epigenetic repression and/or DNA copy-number loss.

27116251

2016