Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The possible localization of Gapdh on MMU16--which may provide a mouse model for Down's syndrome and Alzheimer's disease--may lead to new insights into glycolysis and its role in the two syndromes.
|
7891898 |
1994 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Brain GAPDH activity was normal in all groups with the exception of a slight but statistically significant region-specific reduction in the patients with Huntington disease (caudate nucleus, -12%) and Alzheimer disease (temporal cortex, -19%).
|
9779656 |
1998 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our recent findings (Mazzola and Sirover, 2001) demonstrate a subcellular reduction in GAPDH glycolytic activity in Alzheimer's disease (AD) and in Huntington's disease (HD) cells.
|
12428732 |
2002 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
To assess the importance of potential confounders TaqMan real-time RT-PCR was used to measure seven mRNAs (beta-actin, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), cyclophilin, microtubule-associated protein (MAP) 2, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), amyloid precursor protein (APP) isoform 770) in cortical samples taken from 90 Alzheimer's disease (AD) and 81 control brains.
|
14559355 |
2003 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GAPDH can be used as a endogenous reference gene in the study of AD brains.
|
14687679 |
2004 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interestingly, immunocytochemical examination of human post-mortem materials from patients with Alzheimer's disease revealed nuclear aggregated GAPDH in neurons of the affected brain regions, implying an association with apoptotic cell death.
|
15094325 |
2004 |
Alzheimer's Disease
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis.
|
15507493 |
2004 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis.
|
15507493 |
2004 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
LHGDN |
Our findings suggest that disulfide bonding of GAPDH and subsequent protein aggregate formation may have relevance to the pathophysiology of AD.
|
16186172 |
2005 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
LHGDN |
Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease.
|
16832079 |
2006 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease.
|
16832079 |
2006 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon gamma (INFgamma).
|
17324518 |
2007 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
RGD |
Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon gamma (INFgamma).
|
17324518 |
2007 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon gamma (INFgamma).
|
17324518 |
2007 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
LHGDN |
An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach.
|
17387692 |
2007 |
Alzheimer's Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
When the two family datasets were examined, none of the SNPs were significant in NE families, but two SNPs were associated with AD in Caribbean Hispanics: rs740850 in NCAPD2 (p = 0.0097) and rs1060620 in GAPDH (p = 0.042).
|
18340469 |
2008 |
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Picalm mRNA was elevated in relation to glyceraldehyde-3-phosphate dehydrogenase but not factor VIII-related antigen or CD31 mRNA in the frontal cortex in AD.
|
20838239 |
2010 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Frequently used housekeepers such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin had lower overall expression in AD and AD/LBD cases than in controls.
|
21044776 |
2010 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Clusterin mRNA levels were unchanged when normalized to GAPDH but modestly increased in the frontal and temporal cortex in AD in relation to NSE and MAP-2.
|
22232000 |
2012 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our study adds new insight to previous ones by showing the involvement of GAPDH in AD, which may influence the pathogenesis of this neurodegenerative disease.
|
25022884 |
2014 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Neuroproteomics studies have showed the high affinity interactions between GAPDH - β-amyloid in Alzheimer disease.
|
28087189 |
2017 |
Alzheimer's Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Preventing the increase in GAPDH-SNO abundance in both cultured neurons and mice, either by overexpression of the nitrosylation mutant of GAPDH (GAPDH C150S) or by treatment with the GAPDH nitrosylation inhibitor CGP3466B (also known as omigapil), abrogated Aβ<sub>1-42</sub>-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that this drug might be repurposed to treat patients with AD.
|
29559585 |
2018 |
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Also the role of GAPDH in neurodegenerative diseases is linked to it directly binding to specific amyloidogenic proteins and petides such as β-amyloid precursor protein, β-amyloid peptide and tau protein in Alzheimer's disease, huntingtin in Huntington's disease and α-synuclein in Parkinson disease.
|
30254002 |
2018 |